Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.

Details

Serval ID
serval:BIB_B8269BD8CA8B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA.
Journal
Science (New York, N.Y.)
Author(s)
Steimle V, Siegrist CA, Mottet A, Lisowska-Grospierre B, Mach B
Publication state
Published
Issued date
07/1994
Peer-reviewed
Oui
Language
english
Abstract
Major histocompatibility complex (MHC) class II genes are expressed constitutively in only a few cell types, but they can be induced in the majority of them, in particular by interferon-gamma (IFN-gamma). The MHC class II transactivator gene CIITA is defective in a form of primary MHC class II deficiency. Here it is shown that CIITA expression is controlled and induced by IFN-gamma. A functional CIITA gene is necessary for class II induction, and transfection of CIITA is sufficient to activate expression of MHC class II genes in class II-negative cells in the absence of IFN-gamma. CIITA is therefore a general regulator of both inducible and constitutive MHC class II expression.
Keywords
MHC-II, CIITA, bare lymphocyte syndrome, IFN-gamma
Pubmed
Create date
23/03/2020 11:44
Last modification date
25/03/2020 6:26
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