[Blocking effect of anisodamine on acetylcholine receptor channels].

Détails

ID Serval
serval:BIB_B821BAD8BAB3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
[Blocking effect of anisodamine on acetylcholine receptor channels].
Périodique
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
Auteur(s)
Zhao C.L., Ron S., Liu C.G., He X.P., Xie Z.P.
ISSN
0253-9756 (Print)
ISSN-L
0253-9756
Statut éditorial
Publié
Date de publication
1993
Peer-reviewed
Oui
Volume
14
Numéro
2
Pages
190-192
Langue
anglais
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Anisodamine, an analog of atropine, was isolated first in China. Patch-clamp technique was used to study the inhibitory effect of anisodamine (Ani) on acetylcholine receptor on the membrane of muscle innervated by neuron. Neural tube in embryo of Xenopus laevis were cultured. By whole-cell clamp and outside-out patch, we found that the inhibitory effect of Ani was obvious on both miniature end-plate currents (MEPC) and single channel. This effect was reversible and the minimal concentration for complete inhibition was 60 mumol.L-1, vs 1 and 0.5 mmol.L-1 for atropine and scopolamine, respectively. Our results indicate that Ani blocks both M-ACh and N-ACh receptors.
Mots-clé
Animals, Atropine/pharmacology, Cells, Cultured, Electrophysiology, Embryo, Nonmammalian, Motor Endplate/physiology, Receptors, Muscarinic/drug effects, Receptors, Nicotinic/drug effects, Scopolamine Hydrobromide/pharmacology, Solanaceous Alkaloids/pharmacology, Xenopus laevis
Pubmed
Création de la notice
29/10/2013 11:11
Dernière modification de la notice
20/08/2019 15:26
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