A common biological basis of obesity and nicotine addiction.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_B81330AE7F71
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A common biological basis of obesity and nicotine addiction.
Journal
Translational psychiatry
Working group(s)
TAG Consortium, Oxford-GSK Consortium, ENGAGE consortium
Contributor(s)
Kim Y.J., Dackor J., Boerwinkle E., Franceschini N., Ardissino D., Bernardinelli L., Mannucci P.M., Mauri F., Merlini P.A., Absher D., Assimes T.L., Fortmann S.P., Iribarren C., Knowles J.W., Quertermous T., Ferrucci L., Tanaka T., Bis J.C., Furberg C.D., Haritunians T., McKnight B., Psaty B.M., Taylor K.D., Thacker E.L., Almgren P., Groop L., Ladenvall C., Boehnke M., Jackson A.U., Mohlke K.L., Stringham H.M., Tuomilehto J., Benjamin E.J., Hwang S.J., Levy D., Preis S.R., Vasan R.S., Duan J., Gejman P.V., Levinson D.F., Sanders A.R., Shi J., Lips E.H., McKay J.D., Agudo A., Barzan L., Bencko V., Benhamou S., Castellsagué X., Canova C., Conway D.I., Fabianova E., Foretova L., Janout V., Healy C.M., Holcátová I., Kjaerheim K., Lagiou P., Lissowska J., Lowry R., Macfarlane T.V., Mates D., Richiardi L., Rudnai P., Szeszenia-Dabrowska N., Zaridze D., Znaor A., Lathrop M., Brennan P., Bandinelli S., Frayling T.M., Guralnik J.M., Milaneschi Y., Perry J.R., Altshuler D., Elosua R., Kathiresan S., Lucas G., Melander O., O'Donnell C.J., Salomaa V., Schwartz S.M., Voight B.F., Penninx B.W., Smit J.H., Vogelzangs N., Boomsma D.I., de Geus E.J., Vink J.M., Willemsen G., Chanock S.J., Gu F., Hankinson S.E., Hunter D.J., Hofman A., Tiemeier H., Uitterlinden A.G., van Duijn C.M., Walter S., Chasman D.I., Everett B.M., Paré G., Ridker P.M., Li M.D., Maes H.H., Audrain-McGovern J., Posthuma D., Thornton L.M., Lerman C., Kaprio J., Rose J.E., Ioannidis J.P., Kraft P., Lin D.Y., Liu J.S., Tozzi F., Waterworth D.M., Pillai S.G., Muglia P., Middleton L., Berrettini W., Knouff C.W., Yuan X., Waeber G., Vollenweider P., Preisig M., Wareham N.J., Zhao J.H., Loos R.J., Barroso I., Khaw K.T., Grundy S., Barter P., Mahley R., Kesaniemi A., McPherson R., Vincent J., Strauss J., Kennedy J., Farmer A., McGuffin P., Day R., Matthews K., Bakke P., Gulsvik A., Lucae S., Ising M., Brueckl T., Horstmann S., Heinrich J., Rawal R., Dahmen N., Lamina C., Polasek O., Zgaga L., Huffman J., Campbell S., Kooner J., Chambers J.C., Burnett M.S., Devaney J., Pichard A.D., Kent K.M., Satler L., Lindsay J.M., Waksman R., Epstein S., Wilson J.F., Wild S.H., Campbell H., Vitart V., Reilly M.P., Li M., Qu L., Wilensky R., Matthai W., Hakonarson H.H., Rader D.J., Franke A., Wittig M., Schäfer A., Uda M., Terracciano A., Xiao X., Busonero F., Scheet P., Schlessinger D., St Clair D., Rujescu D., Abecasis G.R., Grabe H.J., Teumer A., Völzke H., Petersmann A., John U., Rudan I., Hayward C., Wright A.F., Kolcic I., Wright B.J., Thompson J.R., Balmforth A.J., Hall A.S., Samani N.J., Anderson C.A., Ahmed T., Mathew C.G., Parkes M., Satsangi J., Caulfield M., Munroe P.B., Farrall M., Dominiczak A., Worthington J., Thomson W., Eyre S., Barton A., Mooser V., Francks C., Surakka I., Vink J.M., Amin N., Geller F., Rafnar T., Esko T., Walter S., Gieger C., Rawal R., Mangino M., Prokopenko I., Mägi R., Keskitalo K., Gudjonsdottir I.H., Gretarsdottir S., Stefansson H., Aulchenko Y.S., Nelis M., Aben K.K., den Heijer M., Soranzo N., Valdes A.M., Steves C., Uitterlinden A.G., Hofman A., Tönjes A., Kovacs P., Hottenga J.J., Willemsen G., Vogelzangs N., Döring A., Dahmen N., Nitz B., Ripatti S., Perola M., Kettunen J., Hartikainen A.L., Pouta A., Laitinen J., Isohanni M., Huei-Yi S., Allen M., Krestyaninova M., Hall A.S., Thompson J.R., Oskarsson H., Tyrfingsson T., Kiemeney L.A., Järvelin M.R., Salomaa V., Stumvoll M., Spector T.D., Wichmann H.E., Metspalu A., Samani N.J., Penninx B.W., Oostra B.A., Boomsma D.I., Tiemeier H., van Duijn C.M., Kaprio J., Gulcher J.R.
ISSN
2158-3188
ISSN-L
2158-3188
Publication state
Published
Issued date
01/10/2013
Peer-reviewed
Oui
Volume
3
Number
10
Pages
e308
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34,216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10(-7)). These findings replicate in a second large data set (N=127,274, thereof 76,242 smokers) for both SI (P=1.2 × 10(-5)) and CPD (P=9.3 × 10(-5)). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.
Keywords
Age of Onset, Behavior, Addictive/genetics, Body Mass Index, Humans, Iceland/epidemiology, Obesity/genetics, Polymorphism, Single Nucleotide, Smoking/epidemiology, Smoking/genetics, Tobacco Use Disorder/genetics
Pubmed
Web of science
Open Access
Yes
Create date
16/01/2014 16:08
Last modification date
09/08/2024 15:05
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