Copeptin as a diagnostic biomarker for sepsis-related deaths.

Détails

ID Serval
serval:BIB_B810043173AA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Copeptin as a diagnostic biomarker for sepsis-related deaths.
Périodique
Peptides
Auteur(s)
Palmiere C., Augsburger M.
ISSN
1873-5169 (Electronic)
ISSN-L
0196-9781
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
59
Pages
75-78
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Copeptin has been shown to increase in patients with sepsis, severe sepsis and septic shock. In the study herein described, copeptin was measured in a series of sepsis-related fatalities and control cases that underwent medico-legal investigations. No age-dependent differences in copeptin levels in either sepsis or control cases were observed. No correlation between copeptin concentrations and postmortem interval was identified in either group. Copeptin levels were significantly higher in sepsis cases. Moreover, copeptin concentrations in septic cases correlated with procalcitonin, C-reactive protein and interleukin 6 values. These preliminary findings seem to indicate that copeptin can be reliably measured in biological samples collected during postmortem investigations. These results also suggest that hemodynamic instability associated with sepsis and septic shock can be characterized by copeptin measurement also in the forensic casework.
Pubmed
Web of science
Création de la notice
02/10/2014 17:27
Dernière modification de la notice
20/08/2019 15:26
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