Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing.

Details

Serval ID
serval:BIB_B7D39DF5C459
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing.
Journal
Biochemical Society Transactions
Author(s)
Tan N.S., Michalik L., Di-Poï N., Desvergne B., Wahli W.
ISSN
0300-5127 (Print)
ISSN-L
0300-5127
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
32
Number
Pt 1
Pages
97-102
Language
english
Abstract
The PPARs (peroxisome-proliferator-activated receptors) alpha, beta/delta and gamma belong to the nuclear hormone receptor superfamily. While all three receptors are undetectable in adult mouse interfollicular epidermis, PPARbeta expression and activity is strongly re-activated by inflammatory stimuli during epidermal injury. The pro-inflammatory cytokine TNFalpha (tumour necrosis factor alpha) stimulates transcription of the PPARbeta gene via an activator protein-1 site in its promoter and it also triggers the production of PPARbeta ligands in keratinocytes. This increase of PPARbeta activity in these cells up-regulates the expression of integrin-linked kinase and 3-phosphoinositide-dependent kinase-1, which phosphorylates protein kinase B-alpha (Akt1). The resulting increase in Akt1 activity suppresses apoptosis and ensures the presence of a sufficient number of viable keratinocytes at the wound margin for re-epithelialization. Together, these observations reveal that PPARbeta takes on multiple roles and contributes favourably to the process of wound closure.
Keywords
Animals, Cell Transformation, Neoplastic/metabolism, Cell Transformation, Neoplastic/pathology, Protein-Serine-Threonine Kinases/metabolism, Proto-Oncogene Proteins/metabolism, Proto-Oncogene Proteins c-akt, Receptors, Cytoplasmic and Nuclear/metabolism, Skin/metabolism, Skin/pathology, Transcription Factors/metabolism, Wound Healing
Pubmed
Web of science
Create date
24/01/2008 15:27
Last modification date
20/08/2019 15:25
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