Deficit of verb generation in nondemented patients with Parkinson's disease.

Détails

ID Serval
serval:BIB_B7C5105C529A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Deficit of verb generation in nondemented patients with Parkinson's disease.
Périodique
Movement Disorders
Auteur(s)
Péran P., Rascol O., Démonet J.F., Celsis P., Nespoulous J.L., Dubois B., Cardebat D.
ISSN
0885-3185 (Print)
ISSN-L
0885-3185
Statut éditorial
Publié
Date de publication
2003
Peer-reviewed
Oui
Volume
18
Numéro
2
Pages
150-156
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. PDF type: Research Article
Résumé
Clinical and neuroimaging studies have shown that verb processing suggests a preferential participation of a prefrontal network, which is dysfunctional in Parkinson's disease (PD). To assess a verb processing deficit in PD, we compared noun- and verb-generation tasks for 34 nondemented PD patients (according to the Dementia Rating Scale) with 34 matched normal subjects, using two intracategory tasks (noun/noun and verb/verb generation) and two intercategory tasks (noun/verb and verb/noun generation). PD patients were significantly impaired in the two tasks involving verb production, i.e., verb/verb and noun/verb generation, whereas their performance was similar to those of controls in the two tasks requiring noun production. For the two impaired tasks, we assessed 1) the influence of lexical competition that corresponds to the presence of several candidate words for a given stimulus; 2) the influence of slight cognitive dysfunction; and 3) the influence of motor deficit. Significant correlations were found between DRS scores and performance on the noun/verb task, and no significant correlations were found between lexical competition or motor deficit and performance. The specific deficit for verb production in PD patients is discussed in relation to deficits affecting either action or grammatical representations.
Mots-clé
Antiparkinson Agents/therapeutic use, Cognition, Female, Humans, Language Disorders/diagnosis, Language Disorders/etiology, Language Tests, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease/complications, Parkinson Disease/drug therapy, Prefrontal Cortex/physiopathology, Severity of Illness Index, Vocabulary
Pubmed
Web of science
Création de la notice
24/03/2013 18:34
Dernière modification de la notice
20/08/2019 16:25
Données d'usage