Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?

Details

Serval ID
serval:BIB_B7C356E04260
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?
Journal
European Respiratory Journal
Author(s)
Smit Lidwien A.M., Strachan David P., Vermeulen Roel, de Bakker Paul I.W., Demenais Florence, Dumas Orianne, Carsin Anne-Elie, Cullinan Paul, Curjuric Ivan, Ghosh Rebecca E., Heederik Dick, Imboden Medea, Jarvis Deborah, Lathrop Mark, Le Moual Nicole, Mehta Amar, Miedinger David, Sigsgaard Torben, Siroux Valerie, Vernez David, Zock Jan Paul, Kauffmann Francine, Probst-Hensch Nicole, Kogevinas Manolis, Bouzigon Emmanuelle
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
44
Number
5
Pages
1234-1242
Language
english
Abstract
Recently, a locus centred on rs9273349 in the HLA-DQ region emerged from genome-wide association studies of adult-onset asthma. We aimed to further investigate the role of human leukocyte antigen (HLA) class II in adult-onset asthma and a possible interaction with occupational exposures. We imputed classical HLA-II alleles from 7579 single-nucleotide polymorphisms in 6025 subjects (1202 with adult-onset asthma) from European cohorts: ECRHS, SAPALDIA, EGEA and B58C, and from surveys of bakers and agricultural workers. Based on an asthma-specific job-exposure matrix, 2629 subjects had ever been exposed to high molecular weight (HMW) allergens. We explored associations between 23 common HLA-II alleles and adult-onset asthma, and tested for gene-environment interaction with occupational exposure to HMW allergens. Interaction was also tested for rs9273349. Marginal associations of classical HLA-II alleles and adult-onset asthma were not statistically significant. Interaction was detected between the DPB1*03:01 allele and exposure to HMW allergens (p = 0.009), in particular to latex (p = 0.01). In the unexposed group, the DPB1*03:01 allele was associated with adult-onset asthma (OR 0.67, 95%CI 0.53-0.86). HMW allergen exposures did not modify the association of rs9273349 with adult-onset asthma. Common classical HLA-II alleles were not marginally associated with adult-onset asthma. The association of latex exposure and adult-onset asthma may be modified by DPB1*03:01.
Keywords
Humans , HLA-D Antigens , Asthma , Occupational Exposure , Occupational Health
Pubmed
Web of science
Open Access
Yes
Create date
06/10/2014 10:13
Last modification date
20/08/2019 15:25
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