Congenital clubfoot in Europe: A population-based study.

Détails

ID Serval
serval:BIB_B7076E64684F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Congenital clubfoot in Europe: A population-based study.
Périodique
American journal of medical genetics. Part A
Auteur(s)
Wang H., Barisic I., Loane M., Addor M.C., Bailey L.M., Gatt M., Klungsoyr K., Mokoroa O., Nelen V., Neville A.J., O'Mahony M., Pierini A., Rissmann A., Verellen-Dumoulin C., de Walle HEK, Wiesel A., Wisniewska K., de Jong-van den Berg LTW, Dolk H., Khoshnood B., Garne E.
ISSN
1552-4833 (Electronic)
ISSN-L
1552-4825
Statut éditorial
Publié
Date de publication
04/2019
Peer-reviewed
Oui
Volume
179
Numéro
4
Pages
595-601
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We aimed to assess prevalence, birth outcome, associated anomalies and prenatal diagnosis of congenital clubfoot in Europe using data from the EUROCAT network, and to validate the recording of congenital clubfoot as a major congenital anomaly by EUROCAT registries. Cases of congenital clubfoot were included from 18 EUROCAT registries covering more than 4.8 million births in 1995-2011. Cases without chromosomal anomalies born during 2005-2009, were randomly selected for validation using a questionnaire on diagnostic details and treatment. There was 5,458 congenital clubfoot cases of which 5,056 (93%) were liveborn infants. Total prevalence of congenital clubfoot was 1.13 per 1,000 births (95% CI 1.10-1.16). Prevalence of congenital clubfoot without chromosomal anomaly was 1.08 per 1,000 births (95% CI 1.05-1.11) and prevalence of isolated congenital clubfoot was 0.92 per 1,000 births (95% CI 0.90-0.95), both with decreasing trends over time and large variations in prevalence by registry. The majority of cases were isolated congenital clubfoot (82%) and 11% had associated major congenital anomalies. Prenatal detection rate of isolated congenital clubfoot was 22% and increased over time. Among 301 validated congenital clubfoot cases, diagnosis was confirmed for 286 (95%). In conclusion, this large population-based study found a decreasing trend of congenital clubfoot in Europe after 1999-2002, an increasing prenatal detection rate, and a high standard of coding of congenital clubfoot in EUROCAT.
Mots-clé
associated anomalies, congenital lubfoot, prenatal diagnosis, prevalence, trend
Pubmed
Web of science
Création de la notice
25/03/2019 10:06
Dernière modification de la notice
20/08/2019 15:25
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