Chloride transport in the mammalian proximal tubule

Détails

ID Serval
serval:BIB_B6DAA0224DAA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Chloride transport in the mammalian proximal tubule
Périodique
Pflügers Archiv : European Journal of Physiology
Auteur(s)
Schild  L., Giebisch  G., Karniski  L., Aronson  P. S.
ISSN
0031-6768 (Print)
Statut éditorial
Publié
Date de publication
1986
Volume
407
Numéro
Suppl 2
Pages
S156-S159
Notes
In Vitro
Résumé
Possible transport mechanisms of chloride across the mammalian proximal tubule include both active and passive components and, accordingly, transcellular and intercellular transport routes. Experiments are described in which the possibility of electroneutral anion exchange across the apical cell membrane of proximal tubule cells is evaluated. Experiments in brushborder vesicles of the rabbit kidney cortex have shown the existence of a chloride/formate exchange process. In addition, evidence is presented that formic acid is crossing the brushborder membrane of rabbit renal cortex by non-ionic diffusion. A transport schema is developed in which formate/chloride exchange and sodium/hydrogen exchange in parallel with recycling of formic acid by non-ionic diffusion can account for the electroneutral transport of sodium chloride. Perfusion studies in isolated rabbit straight and convoluted tubules show significant transport stimulation by submillimolar concentrations of formate. Thus, chloride/formate exchange is a possible mechanism for active, transcellular chloride movement across the mammalian proximal tubule.
Mots-clé
Animals Biological Transport, Active Chlorides/*metabolism Formates/metabolism Hydrogen-Ion Concentration Kidney Tubules, Proximal/*metabolism Male Microvilli/metabolism Rabbits
Pubmed
Web of science
Création de la notice
24/01/2008 13:56
Dernière modification de la notice
20/08/2019 16:25
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