Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Is the fixed-dose combination of telmisartan and hydrochlorothiazide a good approach to treat hypertension?
Vascular Health and Risk Management
Publication types: Journal Article ; Review
Blockade of the renin-angiotensin system with selective AT1 receptor antagonists is recognized as an effective mean to lower blood pressure in hypertensive patients. Among the class of AT1 receptor antagonists, telmisartan offers the advantage of a very long half-life. This enables blood pressure control over 24 hours using once-daily administration. The combination of telmisartan with hydrochlorothiazide is a logical step because numerous previous studies have demonstrated that sodium depletion enhances the antihypertensive efficacy of drugs interfering with the activity of the renin-angiotensin system (RAS). In accordance with past experience using similar compounds blocking the RAS, several controlled studies have now demonstrated that the fixed-dose combination oftelmisartan/hydrochlorothiazide is superior in lowering blood pressure than either telmisartan or hydrochlorothiazide alone. Of clinical interest also is the observation that the excellent clinical tolerance of the angiotensin II receptor antagonist is not affected by the association of the low-dose thiazide. Thus telmisartan/hydrochlorothiazide is an effective and well-tolerated antihypertensive combination. Finally, the development of fixed-dose combinations should improve drug adherence because of the one-pill-a-day regimen.
Angiotensin II Type 1 Receptor Blockers/pharmacology, Angiotensin II Type 1 Receptor Blockers/therapeutic use, Antihypertensive Agents/pharmacology, Antihypertensive Agents/therapeutic use, Benzimidazoles/pharmacology, Benzimidazoles/therapeutic use, Benzoates/pharmacology, Benzoates/therapeutic use, Drug Therapy, Combination, Humans, Hydrochlorothiazide/pharmacology, Hydrochlorothiazide/therapeutic use, Hypertension/drug therapy, Randomized Controlled Trials as Topic, Renin-Angiotensin System/drug effects
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