Cellular perspectives on the glutamate-monoamine interactions in limbic lobe structures and their relevance for some psychiatric disorders.

Détails

ID Serval
serval:BIB_B6AEBE74B3A2
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cellular perspectives on the glutamate-monoamine interactions in limbic lobe structures and their relevance for some psychiatric disorders.
Périodique
Progress in neurobiology
Auteur(s)
Pralong E., Magistretti P., Stoop R.
ISSN
0301-0082
Statut éditorial
Publié
Date de publication
2002
Peer-reviewed
Oui
Volume
67
Numéro
3
Pages
173-202
Langue
anglais
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Résumé
Dopaminergic, serotonergic and noradrenergic nuclei form the trimonoamine modulating system (TMMS). This system modulates emotional/motivational activities mediated by the limbic circuitry, where glutamate is the major excitatory neurotransmitter. Two main concepts are the basis of this review. First, since 1950 and the discovery of the antipsychotic activity of the dopamine D2 receptor antagonist chlorpromazine, it appears that drugs that can modulate the TMMS possess therapeutic psychiatric properties. Second, the concept of glutamate/trimonoamine imbalance in the cortico-striato-thalamo-cortical loop that has been so successful in explaining the pathophysiology of Parkinson disease has been applied in the pathophysiology of schizophrenia. This review will focus on the complex interactions between the fast synaptic glutamatergic transmission and the TMMS in specific parts of the limbic lobe and we will try to link these interactions to some psychiatric disorders, mainly depression, schizophrenia and drug addiction.
Mots-clé
Bipolar Disorder, Brain, Depressive Disorder, Dopamine, Glutamic Acid, Humans, Limbic System, Neurotransmitter Agents, Norepinephrine, Receptors, Dopamine, Receptors, Serotonin, Schizophrenia, Serotonin
Pubmed
Web of science
Création de la notice
11/03/2008 10:57
Dernière modification de la notice
20/08/2019 15:25
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