Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
The paracaspase MALT1: biological function and potential for therapeutic inhibition.
Cellular and Molecular Life Sciences
The paracaspase MALT1 has a central role in the activation of lymphocytes and other immune cells including myeloid cells, mast cells and NK cells. MALT1 activity is required not only for the immune response, but also for the development of natural Treg cells that keep the immune response in check. Exaggerated MALT1 activity has been associated with the development of lymphoid malignancies, and recently developed MALT1 inhibitors show promising anti-tumor effects in xenograft models of diffuse large B cell lymphoma. In this review, we provide an overview of the present understanding of MALT1's function, and discuss possibilities for its therapeutic targeting based on recently developed inhibitors and animal models.
Amino Acid Motifs, Animals, B-Lymphocytes/metabolism, B-Lymphocytes/physiology, Caspases/metabolism, Caspases/physiology, Humans, Immunomodulation/genetics, Killer Cells, Natural/metabolism, Killer Cells, Natural/physiology, Lymphoma, Large B-Cell, Diffuse/genetics, Models, Molecular, NF-kappa B/metabolism, NF-kappa B/physiology, Neoplasm Proteins/antagonists & inhibitors, Neoplasm Proteins/metabolism, RNA Stability, RNA, Messenger/metabolism, Transcription Factor AP-1/metabolism, Transcription Factor AP-1/physiology
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