Article: article from journal or magazin.
Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule.
Journal of Virology
To study the major histocompatibility complex class II I-E dependence of mouse mammary tumor virus (MMTV) superantigens, we constructed hybrids between the I-E-dependent MMTV(GR) and the I-E-independent mtv-7 superantigens and tested them in vivo. Our results suggest that, although the C-terminal third mediates I-A interaction, additional binding sites are located elsewhere in the superantigen.
Amino Acid Sequence, Animals, Antigens, Viral/genetics, Antigens, Viral/immunology, CD4-Positive T-Lymphocytes/immunology, Cell Line, Epitopes, T-Lymphocyte/genetics, Epitopes, T-Lymphocyte/immunology, Histocompatibility Antigens Class II/genetics, Histocompatibility Antigens Class II/immunology, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/immunology, Membrane Glycoproteins/genetics, Membrane Glycoproteins/immunology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Molecular Sequence Data, Receptors, Antigen, T-Cell, alpha-beta/immunology, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/immunology, Superantigens/genetics, Superantigens/immunology
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