Early diagnosis of invasive mould infections and disease.

Details

Serval ID
serval:BIB_B67261FB18B2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Early diagnosis of invasive mould infections and disease.
Journal
The Journal of antimicrobial chemotherapy
Author(s)
Lamoth F., Calandra T.
ISSN
1460-2091 (Electronic)
ISSN-L
0305-7453
Publication state
Published
Issued date
01/03/2017
Peer-reviewed
Oui
Volume
72
Number
suppl_1
Pages
i19-i28
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Invasive mould infections (IMIs), such as invasive aspergillosis or mucormycosis, are a major cause of death in patients with haematological cancer and in patients receiving long-term immunosuppressive therapy. Early diagnosis and prompt initiation of antifungal therapy are crucial steps in the management of patients with IMI. The diagnosis of IMI remains a major challenge, with an increased spectrum of fungal pathogens and a diversity of clinical and radiological presentations within the expanding spectrum of immunocompromised hosts. Diagnosis is difficult to establish and is expressed on a scale of probability (proven, probable and possible). Imaging (CT scan), microbiological tools (direct examination, culture, PCR, fungal biomarkers) and histopathology are the pillars of the diagnostic work-up of IMI. None of the currently available diagnostic tests provides sufficient sensitivity and specificity alone, so the optimal approach relies on a combination of multiple diagnostic strategies, including imaging, fungal biomarkers (galactomannan and 1,3-β-d-glucan) and molecular tools. In recent years, the development of PCR for filamentous fungi (primarily Aspergillus or Mucorales) and the progress made in the standardization of fungal PCR technology, may lead to future advances in the field. The appropriate diagnostic approach for IMI should be individualized to each centre, taking into account the local epidemiology of IMI and the availability of diagnostic tests.

Keywords
Aspergillosis/diagnosis, Aspergillosis/diagnostic imaging, Aspergillosis/immunology, Aspergillus fumigatus, Early Diagnosis, Hematologic Neoplasms/drug therapy, Hematologic Neoplasms/immunology, Humans, Immunocompromised Host, Immunosuppression, Invasive Fungal Infections/diagnosis, Invasive Fungal Infections/immunology, Invasive Fungal Infections/microbiology, Magnetic Resonance Imaging/methods, Mannans/blood, Mucor, Mucormycosis/diagnosis, Mucormycosis/diagnostic imaging, Mucormycosis/immunology, Organ Transplantation/adverse effects, Polymerase Chain Reaction/methods, Positron Emission Tomography Computed Tomography/methods, Tomography, X-Ray Computed/methods, beta-Glucans/blood
Pubmed
Web of science
Open Access
Yes
Create date
04/04/2017 17:13
Last modification date
20/08/2019 15:24
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