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Les sites fragiles autosomiques. [[Autosomal fragile sites].
Journal de Génétique Humaine
It is possible to distribute the 17 autosomic fragile sites presently known in three categories according to their sensitivity: BrdU-sensitive sites (10q25, 16q22, 17p12), distamycin A-sensitive sites (16q22, 17p12) and folate- and thymidilate-sensitive sites (2q11-q14, 3p14, 6p23, 7p11, 8q22, 9p21, 9q32, 10q23, 11q13, 11q23, 12q13, 16p12, 16q23, 17p12, 20p11). Four fundamental problems are discussed, first the relation between the presence of a fragile site and the phenotype, secondly the incidence of autosomic sites, third the origin of fragility (particularity of DNA structure, defect of the DNA/proteins binding and abnormal arrangement of chromatin, abnormality of the metaphasic scaffold) and fourth the localization of fragile sites.
Adolescent, Adult, Bromodeoxyuridine, Child, Child, Preschool, Chromosome Aberrations, Chromosome Banding, Chromosome Disorders, Chromosome Fragile Sites, Chromosome Fragility, Chromosomes, Chromosomes, Human, 6-12 and X, Distamycins, Female, Folic Acid, Humans, Infant, Infant, Newborn, Male, Phenotype, Thymidine
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