Replication study of plasma proteins relating to Alzheimer's pathology.
Details
Serval ID
serval:BIB_B5EE9E09DA36
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Replication study of plasma proteins relating to Alzheimer's pathology.
Journal
Alzheimer's & dementia
ISSN
1552-5279 (Electronic)
ISSN-L
1552-5260
Publication state
Published
Issued date
09/2021
Peer-reviewed
Oui
Volume
17
Number
9
Pages
1452-1464
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
This study sought to discover and replicate plasma proteomic biomarkers relating to Alzheimer's disease (AD) including both the "ATN" (amyloid/tau/neurodegeneration) diagnostic framework and clinical diagnosis.
Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment [MCI], and 191 AD) were measured using both SOMAscan and targeted assays, including 4001 and 25 proteins, respectively.
Protein co-expression network analysis of SOMAscan data revealed the relation between proteins and "N" varied across different neurodegeneration markers, indicating that the ATN variants are not interchangeable. Using hub proteins, age, and apolipoprotein E ε4 genotype discriminated AD from controls with an area under the curve (AUC) of 0.81 and MCI convertors from non-convertors with an AUC of 0.74. Targeted assays replicated the relation of four proteins with the ATN framework and clinical diagnosis.
Our study suggests that blood proteins can predict the presence of AD pathology as measured in the ATN framework as well as clinical diagnosis.
Plasma proteins from 972 subjects (372 controls, 409 mild cognitive impairment [MCI], and 191 AD) were measured using both SOMAscan and targeted assays, including 4001 and 25 proteins, respectively.
Protein co-expression network analysis of SOMAscan data revealed the relation between proteins and "N" varied across different neurodegeneration markers, indicating that the ATN variants are not interchangeable. Using hub proteins, age, and apolipoprotein E ε4 genotype discriminated AD from controls with an area under the curve (AUC) of 0.81 and MCI convertors from non-convertors with an AUC of 0.74. Targeted assays replicated the relation of four proteins with the ATN framework and clinical diagnosis.
Our study suggests that blood proteins can predict the presence of AD pathology as measured in the ATN framework as well as clinical diagnosis.
Keywords
Aged, Alzheimer Disease/blood, Alzheimer Disease/pathology, Amyloid beta-Peptides/blood, Apolipoprotein E4/blood, Apolipoprotein E4/genetics, Biomarkers/blood, Blood Proteins, Cognitive Dysfunction/blood, Cognitive Dysfunction/pathology, Europe, Female, Humans, Male, Middle Aged, Proteomics, tau Proteins/blood, ATN framework, Alzheimer's disease, biomarker, dementia, network analysis, plasma proteomics, replication
Pubmed
Web of science
Create date
23/04/2021 16:36
Last modification date
21/01/2022 6:35
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