Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus

Détails

ID Serval
serval:BIB_B5D84C87DE39
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus
Périodique
Journal of Experimental Medicine
Auteur(s)
Speiser  D. E., Lees  R. K., Hengartner  H., Zinkernagel  R. M., MacDonald  H. R.
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
12/1989
Volume
170
Numéro
6
Pages
2165-70
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 1
Résumé
The role of thymic MHC class II-bearing cells in the selection of the TCR repertoire has been investigated in allogeneic radiation bone marrow chimeras. Positive selection of mature CD4+ T lymphocytes expressing the V beta 6+ TCR domain was found to depend upon radioresistant (presumably epithelial) I-E+ thymic cells. On the other hand, negative selection of CD4+ V beta 6+ cells (which was additionally dependent upon expression of the Mls-1a gene product) was controlled by a radiosensitive I-E+ thymic component (most likely dendritic cells). These data argue in favor of a compartmentalization of positive and negative selection events during T cell development.
Mots-clé
Animals Antigens, Surface/genetics H-2 Antigens/genetics Mice Mice, Inbred DBA Minor Lymphocyte Stimulatory Antigens Radiation Tolerance Receptors, Antigen, T-Cell/*physiology T-Lymphocytes/physiology Thymus Gland/*immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:32
Dernière modification de la notice
09/05/2019 0:08
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