Paroxetine-induced modulation of cortical activity supporting language representations of action.

Détails

ID Serval
serval:BIB_B5B118DCF6D2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Paroxetine-induced modulation of cortical activity supporting language representations of action.
Périodique
Psychopharmacology
Auteur(s)
Péran P., Démonet J.F., Cardebat D.
ISSN
0033-3158 (Print)
ISSN-L
0033-3158
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
195
Numéro
4
Pages
487-496
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled TrialPublication Status: ppublish. PDF type: ORIGINAL INVESTIGATION
Résumé
INTRODUCTION: Previous studies have shown that paroxetine, a selective serotonin reuptake inhibitor, affects brain motor pathway activity in healthy subjects using simple motor tasks. In this study, we explored the effects of paroxetine on the activity of cortical areas implicated in higher-order representations of goal-directed movements, i.e., action-related language processing.
MATERIALS AND METHODS: A double-blind, crossover, randomized paradigm was used to compare two 1-month treatment phases with either paroxetine (20 mg per day) or placebo. A functional magnetic resonance imaging experiment on 12 healthy subjects, conducted at the end of each treatment phase, comprised a single list of verbs and three tasks that consisted in repeating the verbs aloud, generating verbs depicting actions aloud, and mentally simulating the corresponding actions. The effects of the drug, i.e., paroxetine-placebo>0 (hyperactivation) and placebo-paroxetine >0 (hypoactivation) were assessed on the basis of the activation-rest contrast for each task.
RESULTS AND DISCUSSION: For both verb generation and mental simulation of action which both engaged higher-order representations of action, we observed hypoactivation in the left-sided prefrontal and right-sided medial premotor cortex. By contrast, we observed hyperactivation in the right-sided Brodmann's area 6 for the less demanding verb repetition task.
CONCLUSION: Chronic treatment with paroxetine may modulate the cerebral activities elicited by action-related language tasks depending on the cognitive components involved in such tasks.
Mots-clé
Cerebral Cortex/drug effects, Comprehension/drug effects, Cross-Over Studies, Dominance, Cerebral/physiology, Double-Blind Method, Female, Frontal Lobe/drug effects, Humans, Image Processing, Computer-Assisted, Imagination/drug effects, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Middle Aged, Paroxetine/pharmacology, Prefrontal Cortex/drug effects, Psychomotor Performance/drug effects, Semantics, Serotonin Uptake Inhibitors/pharmacology, Speech Perception/drug effects, Verbal Behavior/drug effects
Pubmed
Web of science
Création de la notice
24/03/2013 19:57
Dernière modification de la notice
20/08/2019 16:24
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