International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis.

van Huizen, A.M.; Menting, S.P.; Gyulai, R.; Iversen, L.; van der Kraaij, G.E.; Middelkamp-Hup, M.A.; Warren, R.B.; Spuls, P.I.; Schejtman, A.A.; Egeberg, A.; Firooz, A.; Kumar, A.S.; Oakley, A.; Foulkes, A.; Ramos, AMC; Fougerousse, A.C.; Carija, A.; Akman-Karakas, A.; Horváth, B.; Fábos, B.; Matlock, B.H.; Claréus, B.W.; Castro, C.; Ferrándiz, C.; Correa, C.C.; Marchesi, C.; Goujon, C.; Gonzalez, C.; Maldonado-García, C.; Hong, C.H.; Griffiths, CEM; Vestergaard, C.; Echeverría, C.M.; de la Cruz, C.; Conrad, C.; Törocsik, D.; Drvar, D.L.; Balak, D.; Jullien, D.; Appelen, D.; Kim, D.H.; de Jong, EMGJ; El Gamal, E.; Laffitte, E.; Mahé, E.; Sonkoly, E.; Colombo, E.P.; Vilarrasa, E.; Willaert, F.; Novoa, F.D.; Handjani, F.; Valenzuela, F.; Vílchez-Márquez, F.; Gonzalez, G.O.; Krisztián, G.; Damiani, G.; Krnjevic-Pezic, G.; Pellerano, G.; Carretero, G.; Hunter, HJA; Riad, H.; Oon, H.H.; Boonen, HPJ; Moussa, I.O.; García-Doval, I.; Csányi, I.; Brajac, I.; Turchin, I.; Grozdev, I.; Weinberg, J.M.; Nicolopoulos, J.; Wells, J.; Lambert, JLW; Ingram, J.R.; Prinz, J.C.; de Souza Sittart, J.A.; Sanchez, J.L.; Hsiao, J.P.; Castro-Ayarza, J.R.; Maul, J.T.; van den Reek, JMPA; Trcko, K.; Barber, K.; Reich, K.; Gebauer, K.A.; Khobzei, K.; Maul, L.V.; Massari, L.P.; Fardet, L.; le Cleach, L.; Misery, L.; Chandrashekar, L.; Muresanu, L.I.; Lecluse, L.; Skov, L.; Frez, M.L.; Babic, L.T.; Puig, L.; Gomez, L.C.; Ramam, M.; Dutil, M.; El-Sayed, M.H.; Olszewska, M.; Schram, M.E.; Franco, M.D.; Llamas-Velasco, M.; Gonçalo, M.; Velásquez-Lopera, M.M.; Abad, M.E.; de Oliveira, MFSP; Seyger, MMB; Kaštelan, M.; Rademaker, M.; Sikora, M.; Lebwohl, M.; Wiseman, M.C.; Ferran, M.; van Doorn, M.; Danespazhooh, M.; Bylaite-Bucinskiene, M.; Gooderham, M.J.; Polic, M.V.; de Rie, M.A.; Zheng, M.; Gómez-Flores, M.; Salleras I Redonnet, M.; Silverberg, N.B.; Doss, N.; Yawalkar, N.; Chosidow, O.; Zargari, O.; de la Cueva, P.; Fernandez-Peñas, P.; Cárdenas Rojas, P.J.; Gisondi, P.; Grewal, P.; Sator, P.; Luna, P.C.; Félix, PAO; Varela, P.; Holló, P.; Cetkovska, P.; Calzavara-Pinton, P.; Ghislain, P.D.; Araujo, R.R.; Romiti, R.; Kui, R.; Ceovic, R.; Vender, R.; Lafuente-Urrez, R.F.; Del-Río, R.; Gulin, S.J.; Handa, S.; Mahil, S.K.; Kolalapudi, S.A.; Marrón, S.E.; Azimi, S.Z.; Janmohamed, S.R.; da Cruz Costa, S.A.; Choon, S.E.; Urbancek, S.; Ayanlowo, O.; Margasin, S.M.; Wong, T.W.; Mälkönen, T.; Hurtová, T.; Reciné, T.R.; Huldt-Nystrøm, T.; Torres, T.; Liu, T.Y.; Leonidze, T.; Sharma, V.K.; Weightman, W.; Gulliver, W.; Veldkamp, W.

doi:10.1001/jamadermatol.2022.0434

International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis.

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Serval ID

serval:BIB_B539AD0B6ECF

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis.

Journal

JAMA dermatology

Author(s)

van Huizen A.M., Menting S.P., Gyulai R., Iversen L., van der Kraaij G.E., Middelkamp-Hup M.A., Warren R.B., Spuls P.I., Schejtman A.A., Egeberg A., Firooz A., Kumar A.S., Oakley A., Foulkes A., Ramos AMC, Fougerousse A.C., Carija A., Akman-Karakas A., Horváth B., Fábos B., Matlock B.H., Claréus B.W., Castro C., Ferrándiz C., Correa C.C., Marchesi C., Goujon C., Gonzalez C., Maldonado-García C., Hong C.H., Griffiths CEM, Vestergaard C., Echeverría C.M., de la Cruz C., Conrad C., Törocsik D., Drvar D.L., Balak D., Jullien D., Appelen D., Kim D.H., de Jong EMGJ, El Gamal E., Laffitte E., Mahé E., Sonkoly E., Colombo E.P., Vilarrasa E., Willaert F., Novoa F.D., Handjani F., Valenzuela F., Vílchez-Márquez F., Gonzalez G.O., Krisztián G., Damiani G., Krnjevic-Pezic G., Pellerano G., Carretero G., Hunter HJA, Riad H., Oon H.H., Boonen HPJ, Moussa I.O., García-Doval I., Csányi I., Brajac I., Turchin I., Grozdev I., Weinberg J.M., Nicolopoulos J., Wells J., Lambert JLW, Ingram J.R., Prinz J.C., de Souza Sittart J.A., Sanchez J.L., Hsiao J.P., Castro-Ayarza J.R., Maul J.T., van den Reek JMPA, Trcko K., Barber K., Reich K., Gebauer K.A., Khobzei K., Maul L.V., Massari L.P., Fardet L., le Cleach L., Misery L., Chandrashekar L., Muresanu L.I., Lecluse L., Skov L., Frez M.L., Babic L.T., Puig L., Gomez L.C., Ramam M., Dutil M., El-Sayed M.H., Olszewska M., Schram M.E., Franco M.D., Llamas-Velasco M., Gonçalo M., Velásquez-Lopera M.M., Abad M.E., de Oliveira MFSP, Seyger MMB, Kaštelan M., Rademaker M., Sikora M., Lebwohl M., Wiseman M.C., Ferran M., van Doorn M., Danespazhooh M., Bylaite-Bucinskiene M., Gooderham M.J., Polic M.V., de Rie M.A., Zheng M., Gómez-Flores M., Salleras I Redonnet M., Silverberg N.B., Doss N., Yawalkar N., Chosidow O., Zargari O., de la Cueva P., Fernandez-Peñas P., Cárdenas Rojas P.J., Gisondi P., Grewal P., Sator P., Luna P.C., Félix PAO, Varela P., Holló P., Cetkovska P., Calzavara-Pinton P., Ghislain P.D., Araujo R.R., Romiti R., Kui R., Ceovic R., Vender R., Lafuente-Urrez R.F., Del-Río R., Gulin S.J., Handa S., Mahil S.K., Kolalapudi S.A., Marrón S.E., Azimi S.Z., Janmohamed S.R., da Cruz Costa S.A., Choon S.E., Urbancek S., Ayanlowo O., Margasin S.M., Wong T.W., Mälkönen T., Hurtová T., Reciné T.R., Huldt-Nystrøm T., Torres T., Liu T.Y., Leonidze T., Sharma V.K., Weightman W., Gulliver W., Veldkamp W.

Working group(s)

SPIN MTX Consensus Survey Study Group

ISSN

2168-6084 (Electronic)

ISSN-L

2168-6068

Publication state

Published

Issued date

01/05/2022

Peer-reviewed

Oui

Volume

158

Number

Pages

561-572

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.
To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.
Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience).
In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree.
Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients.
In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.

Keywords

Adult, Child, Consensus, Folic Acid, Humans, Methotrexate, Psoriasis/therapy, Surveys and Questionnaires

OAI-PMH

oai:serval.unil.ch:BIB_B539AD0B6ECF

DOI

10.1001/jamadermatol.2022.0434

Pubmed

35353175

Web of science

000776738100004

Create date

09/04/2022 18:13