Article: article from journal or magazin.
Sequential high-dose methotrexate and fluorouracil combined with doxorubicin--a step ahead in the treatment of advanced gastric cancer: a trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cooperative Group.
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial Publication Status: ppublish
In a prospective phase III multicenter trial, 213 patients with advanced measurable or nonmeasurable gastric cancer were randomized to receive methotrexate (MTX), fluorouracil (5-FU), and Adriamycin (doxorubicin; Farmitalia Carlo Erba, Milan, Italy) (FAMTX) or 5-FU, Adriamycin, and mitomycin (FAM). The results show a significantly superior response rate (41% v 9% [P less than .0001]), and survival (median, 42 weeks v 29 weeks [P = .004]) for FAMTX. There was a cumulative thrombocytopenia in FAM and not in FAMTX. The FAMTX protocol should be the reference treatment in future clinical trials that seek to improve the therapeutic outcome in advanced gastric cancer.
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Doxorubicin/administration & dosage, Female, Fluorouracil/administration & dosage, Humans, Male, Methotrexate/administration & dosage, Middle Aged, Neoplasm Staging, Prospective Studies, Remission Induction, Stomach Neoplasms/drug therapy, Stomach Neoplasms/mortality, Survival Analysis
Web of science
Last modification date