Clomiphene citrate effect on testosterone level and semen parameters in 18 infertile men with low testosterone level and normal/low gonadotropines level.

Détails

ID Serval
serval:BIB_B4D1EA355D58
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Clomiphene citrate effect on testosterone level and semen parameters in 18 infertile men with low testosterone level and normal/low gonadotropines level.
Périodique
European journal of obstetrics, gynecology, and reproductive biology
Auteur(s)
Surbone A., Vaucher L., Primi M.P., Leyvraz C., Pitteloud N., Ballabeni P., Mathevet P., Vulliemoz N.
ISSN
1872-7654 (Electronic)
ISSN-L
0301-2115
Statut éditorial
Publié
Date de publication
07/2019
Peer-reviewed
Oui
Volume
238
Pages
104-109
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
To determine the effect of a 3-month course of clomiphene citrate (CC) on plasma testosterone (T) level and on semen parameters in 18 infertile men with low T level and normal or low gonadotropines level.
A retrospective study was conducted by reviewing the medical records of men referred to a university fertility medicine unit for infertility management between January 2010 and March 2015. Men treated with CC for at least 3 months were included if they presented with: RESULTS: 18 patients met the inclusion criteria. CC was prescribed for 3 months at the dose of 50 mg every 48 h. Plasma T level was assessed at baseline and after 1 month of CC administration. Semen parameters were assessed at baseline and after 3 months of CC administration. The median pre-treatment T level was 9.1 nmol/l; after 1 month of CC treatment the median post-treatment T level increased to 20.2 nmol/l (p = <0.001). Median baseline sperm concentration was 7 millions/ml with a median progressive motility of 18%. After 3 months of CC, the median post-treatment sperm concentration was 17.5 millions/ml (p = 0.024) and the median post-treatment progressive sperm motility was 18% (p = 0.40). Three natural pregnancies occurred during the treatment period.
CC is an effective and inexpensive treatment to increase plasma T level in infertile men with low T level and normal or low gonadotropines level. Our study suggests that CC could increase sperm concentration even in oligospermic infertile men, without, however, a significant effect on progressive sperm motility. More powered randomized controlled trials are needed to definitively assess CC effect on sperm parameters and on natural pregnancy rates.
Mots-clé
Clomiphene citrate, Infertility, Sperm parameters, Testosterone
Pubmed
Web of science
Création de la notice
14/06/2019 16:44
Dernière modification de la notice
07/11/2019 14:05
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