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Article: article from journal or magazin.
Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions.
Magnetic Resonance Imaging
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
The relaxivity of commercially available gadolinium (Gd)-based contrast agents was studied for X-nuclei resonances with long intrinsic relaxation times ranging from 6 s to several hundred seconds. Omniscan in pure 13C formic acid had a relaxivity of 2.9 mM(-1) s(-1), whereas its relaxivity on glutamate C1 and C5 in aqueous solution was approximately 0.5 mM(-1) s(-1). Both relaxivities allow the preparation of solutions with a predetermined short T1 and suggest that in vitro substantial sensitivity gains in their measurement can be achieved. 6Li has a long intrinsic relaxation time, on the order of several minutes, which was strongly affected by the contrast agents. Relaxivity ranged from approximately 0.1 mM(-1) s(-1) for Omniscan to 0.3 for Magnevist, whereas the relaxivity of Gd-DOTP was at 11 mM(-1) s(-1), which is two orders of magnitude higher. Overall, these experiments suggest that the presence of 0.1- to 10-microM contrast agents should be detectable, provided sufficient sensitivity is available, such as that afforded by hyperpolarization, recently introduced to in vivo imaging.
Carbon Radioisotopes/pharmacology, Chelating Agents/chemistry, Contrast Media/pharmacology, Formates/chemistry, Gadolinium/pharmacology, Image Processing, Computer-Assisted, Lithium/pharmacology, Magnetic Resonance Imaging/instrumentation, Magnetic Resonance Imaging/methods, Nanoparticles/chemistry, Organometallic Compounds/chemistry, Sensitivity and Specificity, Solutions, Water/chemistry
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