Myc's other life: stem cells and beyond.

Détails

ID Serval
serval:BIB_B465DA21E3FD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Myc's other life: stem cells and beyond.
Périodique
Current Opinion in Cell Biology
Auteur(s)
Laurenti E., Wilson A., Trumpp A.
ISSN
1879-0410 (Electronic)
ISSN-L
0955-0674
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
21
Numéro
6
Pages
844-854
Langue
anglais
Résumé
Over the last three decades genetic and biochemical studies have revealed the pleiotropic effects of the Myc oncoprotein. While cell line studies have defined the intracellular processes regulated by Myc such as proliferation, differentiation, and metabolic growth, in vivo studies have confirmed these functions, and revealed roles in acquisition and maintenance of stem cell properties. These roles may be partially mediated by Myc's capacity to modify the chromatin landscape on a global scale. Myc also regulates numerous protein-coding transcripts, and many noncoding RNAs (rRNAs, tRNAs, and miRNAs). As Myc activity directly correlates with protein expression, further complexity is provided by post-translational modifications that regulate Myc in normal stem cells or deregulate it in malignant stem cells.
Mots-clé
Animals, Cell Differentiation, Cell Proliferation, Cell Transformation, Neoplastic/genetics, Cell Transformation, Neoplastic/metabolism, Epigenesis, Genetic, Humans, MicroRNAs/metabolism, Models, Biological, Neoplastic Stem Cells/cytology, Neoplastic Stem Cells/metabolism, Protein Processing, Post-Translational, Proto-Oncogene Proteins c-myc/genetics, Proto-Oncogene Proteins c-myc/metabolism, RNA, Untranslated/metabolism, Stem Cells/cytology, Stem Cells/metabolism
Pubmed
Web of science
Création de la notice
15/01/2010 14:50
Dernière modification de la notice
20/08/2019 15:22
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