Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis.

Details

Serval ID
serval:BIB_B40ECC585D8B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis.
Journal
Atherosclerosis
Author(s)
Ouyang P., Vaidya D., Dobs A., Golden S.H., Szklo M., Heckbert S.R., Kopp P., Gapstur S.M.
ISSN
1879-1484 (Electronic)
ISSN-L
0021-9150
Publication state
Published
Issued date
05/2009
Peer-reviewed
Oui
Volume
204
Number
1
Pages
255-261
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Abstract
We examined cross-sectional associations between sex hormones and carotid artery intimal-medial thickness (cIMT) and coronary artery calcium in women in the Multi-Ethnic Study of Atherosclerosis. Serum testosterone, estradiol, sex hormone binding globulin (SHBG), and dehydroepiandrosterone levels were measured in 1947 postmenopausal women aged 45-84 years (30% White, 14% Chinese-American, 31% Black, and 25% Hispanic) and not on hormone therapy. Using multiple linear regression we evaluated associations between log(sex hormone) levels and log(cIMT) adjusted for age, ethnicity, body mass index (BMI) and cardiac risk factors. Associations between sex hormone levels and the presence and extent of coronary calcium were evaluated. Total and bioavailable testosterone were positively associated with common cIMT independent of age, BMI, hypertension, smoking, HDL-cholesterol, LDL-cholesterol and insulin sensitivity (p=0.009 and p=0.002, respectively). SHBG was negatively associated with common cIMT (p=0.001) but further adjustment for BMI, cardiovascular risk factors, and LDL- and HDL-cholesterol removed significance. Estradiol and dehydroepiandrosterone were not associated with common cIMT. Sex hormones were not associated with presence of coronary calcium. Among women with measurable coronary calcium, higher SHBG (p=0.012) and lower bioavailable testosterone (p=0.007) were associated with greater coronary calcium score. No heterogeneity by ethnicity was found. In postmenopausal women, testosterone is independently associated with greater common cIMT. SHBG is negatively associated and this may be mediated by LDL- and HDL-cholesterol. In contrast, SHBG and testosterone were associated with extent of coronary calcium but in the opposite direction compared to carotid intimal-medial thickness. These differences warrant further evaluation.
Keywords
Aged, Aged, 80 and over, Calcinosis/blood, Calcinosis/ethnology, Calcinosis/pathology, Carotid Artery Diseases/blood, Carotid Artery Diseases/ethnology, Carotid Artery Diseases/pathology, Coronary Artery Disease/blood, Coronary Artery Disease/ethnology, Coronary Artery Disease/pathology, Cross-Sectional Studies, Dehydroepiandrosterone/blood, Estradiol/blood, Female, Gonadal Steroid Hormones/blood, Humans, Linear Models, Logistic Models, Middle Aged, Postmenopause/blood, Postmenopause/ethnology, Risk Assessment, Risk Factors, Sex Hormone-Binding Globulin/analysis, Testosterone/blood, United States/epidemiology
Pubmed
Web of science
Create date
30/12/2020 14:05
Last modification date
31/12/2020 6:26
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