Metabolism and neurogenesis.

Details

Serval ID
serval:BIB_B3EE52CD0FCA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Metabolism and neurogenesis.
Journal
Current opinion in neurobiology
Author(s)
Knobloch M., Jessberger S.
ISSN
1873-6882 (Electronic)
ISSN-L
0959-4388
Publication state
Published
Issued date
02/2017
Peer-reviewed
Oui
Volume
42
Pages
45-52
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The generation of neurons in the developing and adult mammalian brain by neural stem/progenitor cells (NSPCs) depends on a tight control of NSPC activity and neuronal differentiation that is regulated by a plethora of intrinsic and extrinsic molecular cues. Besides well-studied morphogenic signaling pathways and transcriptional codes that govern the distinct developmental steps from the dividing NSPC to a functional neuron, a critical role of cellular metabolism to determine the functional properties of NSPCs and newborn neurons has been recently identified. Here, we review advances in our understanding of how metabolism affects NSPC behavior and subsequent neuronal differentiation and suggest how metabolism may serve as a common signal integrator to ensure life-long addition of new neurons in the mammalian brain.
Keywords
Animals, Brain/cytology, Brain/embryology, Brain/metabolism, Humans, Neural Stem Cells/cytology, Neural Stem Cells/metabolism, Neurogenesis/physiology, Neurons/cytology, Neurons/metabolism, Signal Transduction
Pubmed
Web of science
Create date
25/05/2018 8:17
Last modification date
20/08/2019 15:22
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