Metabolism and neurogenesis.

Détails

ID Serval
serval:BIB_B3EE52CD0FCA
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Metabolism and neurogenesis.
Périodique
Current opinion in neurobiology
Auteur(s)
Knobloch M., Jessberger S.
ISSN
1873-6882 (Electronic)
ISSN-L
0959-4388
Statut éditorial
Publié
Date de publication
02/2017
Peer-reviewed
Oui
Volume
42
Pages
45-52
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The generation of neurons in the developing and adult mammalian brain by neural stem/progenitor cells (NSPCs) depends on a tight control of NSPC activity and neuronal differentiation that is regulated by a plethora of intrinsic and extrinsic molecular cues. Besides well-studied morphogenic signaling pathways and transcriptional codes that govern the distinct developmental steps from the dividing NSPC to a functional neuron, a critical role of cellular metabolism to determine the functional properties of NSPCs and newborn neurons has been recently identified. Here, we review advances in our understanding of how metabolism affects NSPC behavior and subsequent neuronal differentiation and suggest how metabolism may serve as a common signal integrator to ensure life-long addition of new neurons in the mammalian brain.
Mots-clé
Animals, Brain/cytology, Brain/embryology, Brain/metabolism, Humans, Neural Stem Cells/cytology, Neural Stem Cells/metabolism, Neurogenesis/physiology, Neurons/cytology, Neurons/metabolism, Signal Transduction
Pubmed
Web of science
Création de la notice
25/05/2018 9:17
Dernière modification de la notice
20/08/2019 16:22
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