Emergence of Acquired HIV-1 Drug Resistance Almost Stopped in Switzerland: A 15-Year Prospective Cohort Analysis.

Détails

ID Serval
serval:BIB_B3E6EC9A4633
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Emergence of Acquired HIV-1 Drug Resistance Almost Stopped in Switzerland: A 15-Year Prospective Cohort Analysis.
Périodique
Clinical infectious diseases
Auteur(s)
Scherrer A.U., von Wyl V., Yang W.L., Kouyos R.D., Böni J., Yerly S., Klimkait T., Aubert V., Cavassini M., Battegay M., Furrer H., Calmy A., Vernazza P., Bernasconi E., Günthard H.F., Aubert V., Battegay M., Bernasconi E., Böni J., Braun D.L., Bucher H.C., Burton-Jeangros C., Calmy A., Cavassini M., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Marzolini C., Metzner K., Müller N., Nadal D., Nicca D., Pantaleo G., Rauch A., Regenass S., Rudin C., Schöni-Affolter F., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Vernazza P., Weber R., Yerly S.
Collaborateur(s)
Swiss HIV Cohort Study
Contributeur(s)
Aubert V., Battegay M., Bernasconi E., Böni J., Braun DL., Bucher HC., Burton-Jeangros C., Calmy A., Cavassini M., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux CA., Gorgievski M., Günthard H., Haerry D., Hasse B., Hirsch HH., Hoffmann M., Hösli I., Kahlert C., Kaiser L., Keiser O., Klimkait T., Kouyos R., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Marzolini C., Metzner K., Müller N., Nadal D., Nicca D., Pantaleo G., Rauch A., Regenass S., Rudin C., Schöni-Affolter F., Schmid P., Speck R., Stöckle M., Tarr P., Trkola A., Vernazza P., Weber R., Yerly S.
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Statut éditorial
Publié
Date de publication
15/05/2016
Peer-reviewed
Oui
Volume
62
Numéro
10
Pages
1310-1317
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Drug resistance is a major barrier to successful antiretroviral treatment (ART). Therefore, it is important to monitor time trends at a population level.
We included 11 084 ART-experienced patients from the Swiss HIV Cohort Study (SHCS) between 1999 and 2013. The SHCS is highly representative and includes 72% of patients receiving ART in Switzerland. Drug resistance was defined as the presence of ≥1 major mutation in a genotypic resistance test. To estimate the prevalence of drug resistance, data for patients with no resistance test was imputed based on the patient's risk of harboring drug-resistant viruses.
The emergence of new drug resistance mutations declined dramatically from 401 to 23 patients between 1999 and 2013. The upper estimated prevalence limit of drug resistance among ART-experienced patients decreased from 57.0% in 1999 to 37.1% in 2013. The prevalence of 3-class resistance decreased from 9.0% to 4.4% and was always <0.4% for patients who initiated ART after 2006. Most patients actively participating in the SHCS in 2013 with drug-resistant viruses initiated ART before 1999 (59.8%). Nevertheless, in 2013, 94.5% of patients who initiated ART before 1999 had good remaining treatment options based on Stanford algorithm.
Human immunodeficiency virus type 1 drug resistance among ART-experienced patients in Switzerland is a well-controlled relic from the era before combination ART. Emergence of drug resistance can be virtually stopped with new potent therapies and close monitoring.

Mots-clé
Adult, Anti-HIV Agents/pharmacology, Anti-HIV Agents/therapeutic use, Drug Resistance, Viral/genetics, Female, HIV Infections/drug therapy, HIV Infections/epidemiology, HIV Infections/virology, HIV-1/drug effects, HIV-1/genetics, Humans, Male, Middle Aged, Prevalence, Prospective Studies, Switzerland/epidemiology, HIV-1 drug resistance, antiretroviral activity, emergence, prevalence, treatment-experienced patients
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/03/2016 19:30
Dernière modification de la notice
09/05/2019 0:01
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