Postmortem quantitative 1.5-T MRI for the differentiation and characterization of serous fluids, blood, CSF, and putrefied CSF.

Details

Serval ID
serval:BIB_B3CA2A11915F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Postmortem quantitative 1.5-T MRI for the differentiation and characterization of serous fluids, blood, CSF, and putrefied CSF.
Journal
International journal of legal medicine
Author(s)
Zech W.D., Schwendener N., Persson A., Warntjes M.J., Riva F., Schuster F., Jackowski C.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Publication state
Published
Issued date
09/2015
Peer-reviewed
Oui
Volume
129
Number
5
Pages
1127-1136
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The purpose of the present study was to investigate whether serous fluids, blood, cerebrospinal fluid (CSF), and putrefied CSF can be characterized and differentiated in synthetically calculated magnetic resonance (MR) images based on their quantitative T1, T2, and proton density (PD) values. Images from 55 postmortem short axis cardiac and 31 axial brain 1.5-T MR examinations were quantified using a quantification sequence. Serous fluids, fluid blood, sedimented blood, blood clots, CSF, and putrefied CSF were analyzed for their mean T1, T2, and PD values. Body core temperature was measured during the MRI scans. The fluid-specific quantitative values were related to the body core temperature. Equations to correct for temperature differences were generated. In a 3D plot as well as in statistical analysis, the quantitative T1, T2 and PD values of serous fluids, fluid blood, sedimented blood, blood clots, CSF, and putrefied CSF could be well differentiated from each other. The quantitative T1 and T2 values were temperature-dependent. Correction of quantitative values to a temperature of 37 °C resulted in significantly better discrimination between all investigated fluid mediums. We conclude that postmortem 1.5-T MR quantification is feasible to discriminate between blood, serous fluids, CSF, and putrefied CSF. This finding provides a basis for the computer-aided diagnosis and detection of fluids and hemorrhages.
Keywords
Blood, Body Fluids, Body Temperature, Brain/pathology, Cerebrospinal Fluid, Female, Forensic Pathology, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Models, Biological, Myocardium/pathology, Pericardium/pathology, Postmortem Changes, Thrombosis/pathology
Pubmed
Web of science
Create date
29/06/2020 8:11
Last modification date
20/01/2021 6:26
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