Knocking on GDF15's door for the treatment of type 2 diabetes mellitus.

Details

Serval ID
serval:BIB_B3C5BAE835A3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Knocking on GDF15's door for the treatment of type 2 diabetes mellitus.
Journal
Trends in endocrinology and metabolism
Author(s)
Aguilar-Recarte D., Barroso E., Palomer X., Wahli W., Vázquez-Carrera M.
ISSN
1879-3061 (Electronic)
ISSN-L
1043-2760
Publication state
Published
Issued date
11/2022
Peer-reviewed
Oui
Volume
33
Number
11
Pages
741-754
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Although a large number of drugs are available for the treatment of type 2 diabetes mellitus (T2DM), many patients do not achieve adequate disease control despite adhering to medication. Recent findings indicate that the pharmacological modulation of the stress-induced cytokine growth differentiation factor 15 (GDF15) shows promise for the treatment of T2DM. GDF15 suppresses appetite and reduces inflammation, increases thermogenesis and lipid catabolism, sustains AMP-activated protein kinase (AMPK) activity, and ameliorates insulin resistance and hepatic steatosis. In addition, circulating GDF15 levels are elevated in response to several antidiabetic drugs, including metformin, with GDF15 mediating some of their effects. Here, we review the mechanistic insights into the beneficial effects of recently explored therapeutic approaches that target GDF15 for the treatment of T2DM.
Keywords
Humans, Growth Differentiation Factor 15/metabolism, Diabetes Mellitus, Type 2/drug therapy, Diabetes Mellitus, Type 2/metabolism, AMP-Activated Protein Kinases/metabolism, Hypoglycemic Agents/therapeutic use, Metformin/pharmacology, Metformin/therapeutic use, Lipids, AMPK, GFRAL, NAFLD, inflammation, insulin resistance, myokine
Pubmed
Web of science
Create date
04/10/2022 10:06
Last modification date
02/02/2023 6:52
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