Inhibitory effect of DNA supercoiling on DNA knotting

Détails

ID Serval
serval:BIB_B3C1D95595C0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Inhibitory effect of DNA supercoiling on DNA knotting
Périodique
Bussei Kenkyu
Auteur(s)
Dorier J., Burnier Y., Stasiak A.
ISSN
0525-2997
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
92
Numéro
1
Pages
84-88
Langue
anglais
Résumé
Using numerical simulations we investigated the effect of DNA supercoiling on the topological equilibrium of DNA molecules. We showed that under the steady state conditions that maintain the same effective deficit of the linking number in unknotted and knotted DNA molecules the topological equilibrium results in a much smaller fraction of knots than in the case of torsionally relaxed DNA molecules. Based on these results we propose that one of the important functions of DNA supercoiling is to reduce formation of DNA knots.
Création de la notice
09/11/2009 14:00
Dernière modification de la notice
03/03/2018 20:40
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