Inhibitory effect of DNA supercoiling on DNA knotting

Details

Serval ID
serval:BIB_B3C1D95595C0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Inhibitory effect of DNA supercoiling on DNA knotting
Journal
Bussei Kenkyu
Author(s)
Dorier J., Burnier Y., Stasiak A.
ISSN
0525-2997
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
92
Number
1
Pages
84-88
Language
english
Abstract
Using numerical simulations we investigated the effect of DNA supercoiling on the topological equilibrium of DNA molecules. We showed that under the steady state conditions that maintain the same effective deficit of the linking number in unknotted and knotted DNA molecules the topological equilibrium results in a much smaller fraction of knots than in the case of torsionally relaxed DNA molecules. Based on these results we propose that one of the important functions of DNA supercoiling is to reduce formation of DNA knots.
Create date
09/11/2009 13:00
Last modification date
20/08/2019 15:22
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