A Thalamic Reticular Circuit for Head Direction Cell Tuning and Spatial Navigation.

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License: CC BY 4.0
Serval ID
serval:BIB_B34C4D58957F
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A Thalamic Reticular Circuit for Head Direction Cell Tuning and Spatial Navigation.
Journal
Cell reports
Author(s)
Vantomme G., Rovó Z., Cardis R., Béard E., Katsioudi G., Guadagno A., Perrenoud V., Fernandez LMJ, Lüthi A.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
09/06/2020
Peer-reviewed
Oui
Volume
31
Number
10
Pages
107747
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
As we navigate in space, external landmarks and internal information guide our movement. Circuit and synaptic mechanisms that integrate these cues with head-direction (HD) signals remain, however, unclear. We identify an excitatory synaptic projection from the presubiculum (PreS) and the multisensory-associative retrosplenial cortex (RSC) to the anterodorsal thalamic reticular nucleus (TRN), so far classically implied in gating sensory information flow. In vitro, projections to TRN involve AMPA/NMDA-type glutamate receptors that initiate TRN cell burst discharge and feedforward inhibition of anterior thalamic nuclei. In vivo, chemogenetic anterodorsal TRN inhibition modulates PreS/RSC-induced anterior thalamic firing dynamics, broadens the tuning of thalamic HD cells, and leads to preferential use of allo- over egocentric search strategies in the Morris water maze. TRN-dependent thalamic inhibition is thus an integral part of limbic navigational circuits wherein it coordinates external sensory and internal HD signals to regulate the choice of search strategies during spatial navigation.
Keywords
allocentric, anterior thalamus, burst discharge, chemogenetics, egocentric, optogenetics, perseverance, presubiculum, retrosplenial cortex, synaptic inhibition
Pubmed
Open Access
Yes
Create date
25/06/2020 16:12
Last modification date
16/07/2021 8:13
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