Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP.

Détails

ID Serval
serval:BIB_B348B3168D7F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP.
Périodique
European Respiratory Journal
Auteur(s)
Boeck L., Eggimann P., Smyrnios N., Pargger H., Thakkar N., Siegemund M., Marsch S., Rakic J., Tamm M., Stolz D.
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
37
Numéro
3
Pages
595-603
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Ventilator-associated pneumonia (VAP) affects mortality, morbidity and cost of critical care. Reliable risk estimation might improve end-of-life decisions, resource allocation and outcome. Several scoring systems for survival prediction have been established and optimised over the last decades. Recently, new biomarkers have gained interest in the prognostic field. We assessed whether midregional pro-atrial natriuretic peptide (MR-proANP) and procalcitonin (PCT) improve the predictive value of the Simplified Acute Physiologic Score (SAPS) II and Sequential Related Organ Failure Assessment (SOFA) in VAP. Specified end-points of a prospective multinational trial including 101 patients with VAP were analysed. Death <28 days after VAP onset was the primary end-point. MR-proANP and PCT were elevated at the onset of VAP in nonsurvivors compared with survivors (p = 0.003 and p = 0.017, respectively) and their slope of decline differed significantly (p = 0.018 and p = 0.039, respectively). Patients with the highest MR-proANP quartile at VAP onset were at increased risk for death (log rank p = 0.013). In a logistic regression model, MR-proANP was identified as the best predictor of survival. Adding MR-proANP and PCT to SAPS II and SOFA improved their predictive properties (area under the curve 0.895 and 0.880). We conclude that the combination of two biomarkers, MR-proANP and PCT, improve survival prediction of clinical severity scores in VAP.
Mots-clé
Adult, Aged, Atrial Natriuretic Factor/blood, Biological Markers/metabolism, Calcitonin/blood, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Pneumonia, Ventilator-Associated/mortality, Pneumonia, Ventilator-Associated/therapy, Prospective Studies, Protein Precursors/blood, ROC Curve, Regression Analysis, Risk, Treatment Outcome
Pubmed
Open Access
Oui
Création de la notice
28/01/2011 18:25
Dernière modification de la notice
08/05/2019 23:59
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