Pathogenesis of AF: impact on intracardiac signals.

Details

Serval ID
serval:BIB_B336A9032381
Type
Article: article from journal or magazin.
Collection
Publications
Title
Pathogenesis of AF: impact on intracardiac signals.
Journal
Conference Proceedings : ... Annual International Conference of the Ieee Engineering In Medicine and Biology Society. Ieee Engineering In Medicine and Biology Society. Conference
Author(s)
Shah A.J., Dubois R., Miyazaki S., Jadidi A.S., Scherr D., Wilton S.B., Roten L., Pascale P., Pedersen M., Derval N., Knecht S., Sacher F., Jais P., Narayan S., Hocini M., Haïssaguerre M.
ISSN
1557-170X (Print)
ISSN-L
1557-170X
Publication state
Published
Issued date
2011
Volume
2011
Pages
5523-5526
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is responsible for the highest number of rhythm-related disorders and cardioembolic strokes worldwide. Intracardiac signal analysis during the onset of paroxysmal AF led to the discovery of pulmonary vein as a triggering source of AF, which has led to the development of pulmonary vein ablation--an established curative therapy for drug-resistant AF. Complex, multicomponent and rapid electrical activity widely involving the atrial substrate characterizes persistent/permanent AF. Widespread nature of the problem and complexity of signals in persistent AF reduce the success rate of ablation therapy. Although signal processing applied to extraction of relevant features from these complex electrograms has helped to improve the efficacy of ablation therapy in persistent/permanent AF, improved understanding of complex signals should help to identify sources of AF and further increase the success rate of ablation therapy.
Keywords
Animals, Atrial Fibrillation/physiopathology, Heart Conduction System/physiopathology, Humans, Models, Cardiovascular, Pulmonary Veins/physiopathology
Pubmed
Web of science
Create date
12/06/2014 14:58
Last modification date
20/08/2019 15:21
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