Immunological hallmarks of JC virus replication in multiple sclerosis patients on long-term natalizumab therapy.
Details
Serval ID
serval:BIB_B3369B527251
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunological hallmarks of JC virus replication in multiple sclerosis patients on long-term natalizumab therapy.
Journal
Journal of virology
ISSN
1098-5514 (Electronic)
ISSN-L
0022-538X
Publication state
Published
Issued date
05/2013
Peer-reviewed
Oui
Volume
87
Number
10
Pages
6055-6059
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Progressive multifocal leukoencephalopathy (PML) is the main adverse effect of natalizumab. Detectable JC virus-specific effector memory T-cell (TEM) responses may indicate ongoing JCV replication. We detected JCV-specific TEM responses in blood of patients with multiple sclerosis (MS) treated with natalizumab, including 2 patients with PML. The frequency of detection of these responses increased with the time on natalizumab. Thus, a subset of MS patients exhibit immunological hallmarks of JCV replication during prolonged natalizumab therapy.
Keywords
Adult, Antibodies, Monoclonal, Humanized/administration & dosage, Antibodies, Monoclonal, Humanized/adverse effects, Biological Products/administration & dosage, Biological Products/adverse effects, Female, Humans, Immunologic Factors/administration & dosage, Immunologic Factors/adverse effects, JC Virus/immunology, JC Virus/physiology, Middle Aged, Multiple Sclerosis/drug therapy, Multiple Sclerosis/immunology, Multiple Sclerosis/virology, Natalizumab, T-Lymphocytes/immunology, Virus Replication
Pubmed
Web of science
Open Access
Yes
Create date
12/12/2017 17:30
Last modification date
20/08/2019 15:21