Quantitative T2 Mapping of Acute Pancreatitis.
Details
Serval ID
serval:BIB_B30F85E440DA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quantitative T2 Mapping of Acute Pancreatitis.
Journal
Journal of magnetic resonance imaging
ISSN
1522-2586 (Electronic)
ISSN-L
1053-1807
Publication state
Published
Issued date
14/03/2024
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Publication Status: aheadofprint
Abstract
Quantification of the T2 signal by means of T2 mapping in acute pancreatitis (AP) has the potential to quantify the parenchymal edema. Quantitative T2 mapping may overcome the limitations of previously reported scoring systems for reliable assessment of AP.
To evaluate MR-derived pancreatic T2 mapping values in AP and correlate them with markers of disease severity.
Prospective single-center study.
76 adults with AP (20-91 years, females/males: 39/37).
Fat suppressed multiecho spin-echo prototype sequence to quantify T2 signal at 3T MRI.
The severity of AP was assessed clinically, biologically, and by contrast-enhanced CT (CECT) performed 48-72 hours after symptom onset. MRI was then performed ≤24 hours after CT. Two readers blinded to any clinical information independently evaluated the T2 values by placing three regions of interest inside the pancreatic head, body, and tail on the T2 mapping MR sequence. Results were compared with corresponding CECT images as the standard and clinical severity parameters, using the length of hospital stay as our primary endpoint.
Continuous variables were compared using the Spearman's rank correlation coefficient, analysis of variance (ANOVA) or Student's t-test.
T2 values significantly correlated with the length of hospital stay (r <sub>s</sub> (74) = 0.29), CT severity index (CTSI) (r <sub>s</sub> (73) = 0.61; CTSI 0-3: 72 ± 14 msec, CTSI 4-10: 88 ± 15), intensive care unit (ICU) admission (t(2.77) = -3.41) and presence of organ failure (t(6.72) = -3.42), whereas the CTSI and Ranson score were not significantly related with ICU admission (CTSI: P = 0.24; Ranson score: P = 0.24) and organ failure (CTSI: P = 0.11; Ranson score P = 0.11).
T2 mapping correlates with AP severity parameters and is useful for assessing the severity of AP with higher sensitivity than the usual clinical and radiological scoring systems.
1 TECHNICAL EFFICACY: Stage 2.
To evaluate MR-derived pancreatic T2 mapping values in AP and correlate them with markers of disease severity.
Prospective single-center study.
76 adults with AP (20-91 years, females/males: 39/37).
Fat suppressed multiecho spin-echo prototype sequence to quantify T2 signal at 3T MRI.
The severity of AP was assessed clinically, biologically, and by contrast-enhanced CT (CECT) performed 48-72 hours after symptom onset. MRI was then performed ≤24 hours after CT. Two readers blinded to any clinical information independently evaluated the T2 values by placing three regions of interest inside the pancreatic head, body, and tail on the T2 mapping MR sequence. Results were compared with corresponding CECT images as the standard and clinical severity parameters, using the length of hospital stay as our primary endpoint.
Continuous variables were compared using the Spearman's rank correlation coefficient, analysis of variance (ANOVA) or Student's t-test.
T2 values significantly correlated with the length of hospital stay (r <sub>s</sub> (74) = 0.29), CT severity index (CTSI) (r <sub>s</sub> (73) = 0.61; CTSI 0-3: 72 ± 14 msec, CTSI 4-10: 88 ± 15), intensive care unit (ICU) admission (t(2.77) = -3.41) and presence of organ failure (t(6.72) = -3.42), whereas the CTSI and Ranson score were not significantly related with ICU admission (CTSI: P = 0.24; Ranson score: P = 0.24) and organ failure (CTSI: P = 0.11; Ranson score P = 0.11).
T2 mapping correlates with AP severity parameters and is useful for assessing the severity of AP with higher sensitivity than the usual clinical and radiological scoring systems.
1 TECHNICAL EFFICACY: Stage 2.
Keywords
T2-mapping, acute pancreatitis, magnetic resonance imaging, pancreatic parenchymal edema
Pubmed
Web of science
Open Access
Yes
Create date
18/03/2024 18:02
Last modification date
23/05/2024 7:01