Article: article from journal or magazin.
Determination of the structure of a decay accelerating factor-binding clinical isolate of echovirus 11 allows mapping of mutants with altered receptor requirements for infection1
Journal of Virology
PT - Journal Article PT - Research Support, Non-U.S. Gov't
We have used X-ray crystallography to determine the structure of a decay accelerating factor (DAF)-binding, clinic-derived isolate of echovirus 11 (EV11-207). The structures of the capsid proteins closely resemble those of capsid proteins of other picornaviruses. The structure allows us to interpret a series of amino acid changes produced by passaging EV11-207 in different cell lines as highlighting the locations of multiple receptor-binding sites on the virion surface. We suggest that a DAF-binding site is located at the fivefold axes of the virion, while the binding site for a distinct but as yet unidentified receptor is located within the canyon surrounding the virion fivefold axes
Animals/Antigens,CD55/metabolism/Binding Sites/Capsid/ultrastructure/Capsid Proteins/Cercopithecus aethiops/Crystallography,X-Ray/Enterovirus B,Human/genetics/pathogenicity/HT29 Cells/Humans/Mutation/Receptors,Virus/Vero Cells/Viral Proteins/Virion/Research
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