Increased soluble Flt-1 correlates with delayed graft function and early loss of peritubular capillaries in the kidney graft

Details

Serval ID
serval:BIB_B23A6CD6EDA0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Increased soluble Flt-1 correlates with delayed graft function and early loss of peritubular capillaries in the kidney graft
Journal
Transplantation
Author(s)
Chapal M., Neel M., Le Borgne F., Meffray E., Carceles O., Hourmant M., Giral M., Foucher Y., Moreau A., Fakhouri F.
ISSN
1534-6080 (Electronic)
ISSN-L
0041-1337
Publication state
Published
Issued date
2013
Volume
96
Number
8
Pages
739-44
Language
english
Notes
Chapal, Marion
Neel, Melanie
Le Borgne, Florent
Meffray, Emanuelle
Carceles, Odette
Hourmant, Maryvonne
Giral, Magalie
Foucher, Yohann
Moreau, Anne
Fakhouri, Fadi
eng
Research Support, Non-U.S. Gov't
Transplantation. 2013 Oct 27;96(8):739-44. doi: 10.1097/TP.0b013e31829f4772.
Abstract
BACKGROUND: Ischemia-reperfusion induces tubular and endothelial damage in the renal graft and leads to delayed graft function (DGF) and to an early loss of peritubular capillaries (PTC). Few, if any, clinical studies have assessed the impact of proangiogenic and antiangiogenic factors on endothelial repair during renal transplantation (RT)-related ischemia-reperfusion. METHODS: We prospectively assessed the kinetics of the antiangiogenic factor soluble Fms-like tyrosine kinase-1 (sFlt-1) in 136 consecutive RT patients and analyzed sFlt-1 impact on DGF and PTC loss. RESULTS: sFlt-1 plasma levels increased by twofold to threefold throughout the first week after RT. This increase was more marked in recipients of grafts from deceased donors compared with living donors. Patients with DGF had higher sFlt-1 levels at all time points during the first 7 days after RT and a higher peak sFlt-1 compared with those without DGF. In multivariate analysis, a peak plasma sFlt-1 of 250 pg/mL or higher was associated with 2.5-fold increase in the risk of DGF (P=0.04). Similarly, patients with a peak plasma sFlt-1 of 250 pg/mL or higher had a more pronounced early decrease in PTC compared with those with a peak sFlt-1 less than 250 pg/mL. CONCLUSIONS: sFlt-1 is a new nonimmunologic independent risk factor for DGF and PTC loss. Its inhibition may help improve the outcome of RT.
Keywords
Adult, Aged, Capillaries/pathology, Delayed Graft Function/*blood/*epidemiology/pathology, Female, Humans, Kidney Transplantation/*statistics & numerical data, Kidney Tubules/blood supply/pathology, Living Donors, Male, Middle Aged, Monocytes/metabolism, Postoperative Complications/*blood/*epidemiology/pathology, Prospective Studies, Reperfusion Injury/blood/epidemiology/pathology, Risk Factors, Solubility, Vascular Endothelial Growth Factor Receptor-1/*blood
Pubmed
Create date
01/03/2022 10:18
Last modification date
02/03/2022 6:36
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