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Multipoint linkage mapping of the Xq25-q26 region in a family affected by the X-linked lymphoproliferative syndrome
Journal Article --- Old month value: Dec
We have performed, in a large Swiss family, a study of linkage between various DNA markers in the Xq24-27 region and the locus for the X-linked lymphoproliferative syndrome (XLP). Our results indicated that the marker DXS37 in Xq25-q26 is genetically linked to the XLP syndrome. The multipoint linkage analysis showed that the disease locus is distal to DXS11, but proximal to the hypoxanthine phosphoribosyl-transferase gene (HPRT).
Female Genetic Markers Herpesvirus 4, Human/genetics Humans *Linkage (Genetics) *Lod Score Lymphoproliferative Disorders/*genetics Male Pedigree Polymorphism, Restriction Fragment Length Restriction Mapping *X Chromosome
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