Article: article from journal or magazin.
Differential vascular effects of neuropeptide Y(NPY) selective receptor agonists
Journal Article --- Old month value: Oct 15
Neuropeptide Y (NPY) increases blood pressure either directly or indirectly by potentiating the effect of various vasoconstrictors. Only one (the Y1-receptor) of two subtypes of receptors (Y1 and Y2) is thought to mediate the vascular smooth muscle contraction. To test this hypothesis we challenged isolated rat mesenteric arteries that had a functional endothelium with (1-36) NPY and with specific Y1-receptor ([Leu31, Pro34] NPY) and Y2-receptor ([Ahx5-24, gamma-Glu2-epsilon-Lys30] NPY) agonists. The Y1-receptor agonist elicited a contractile response similar to that of NPY, whereas the Y2-receptor agonist had no effect on wall tension. We also found that the presence of a functional endothelium has no influence on the contractile response to NPY. From these data we conclude that the direct contractile effect of NPY in the mesenteric artery is mediated by stimulation of Y1-receptors and is not endothelium-dependent.
Acetylcholine/pharmacology Animals Endothelium, Vascular/drug effects/physiology Kinetics Male Mesenteric Arteries/drug effects/physiology Muscle Contraction/*drug effects Muscle, Smooth, Vascular/*drug effects/physiology Neuropeptide Y/analogs & derivatives/pharmacology Norepinephrine/pharmacology Peptide Fragments/pharmacology Rats Rats, Wistar Receptors, Neuropeptide Y/*agonists/physiology
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