Article: article from journal or magazin.
CSF cortisol in Alzheimer's disease and mild cognitive impairment.
Neurobiology of Aging
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Hypercortisolaemia occurs in Alzheimer's disease (AD) and may be involved in the AD related neurodegenerative process. In order to determine whether brain structures are exposed to high cortisol concentrations early in AD, we measured cerebrospinal fluid (CSF) cortisol in 66 subjects with AD, 33 subjects with mild cognitive impairment (MCI) and 34 control subjects. CSF cortisol concentrations were higher in AD subjects compared to controls (p<0.001) and to MCI subjects (p=0.002). There was no significant increase of cortisol in MCI subjects compared with controls suggesting that the increase of CSF cortisol is not an early event in the course of AD.
Alzheimer Disease/cerebrospinal fluid, Alzheimer Disease/diagnosis, Biological Markers/cerebrospinal fluid, Cognition Disorders/cerebrospinal fluid, Cognition Disorders/diagnosis, Humans, Hydrocortisone/cerebrospinal fluid, Neuropsychological Tests
Last modification date