MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells.

Détails

ID Serval
serval:BIB_B11F6E25F688
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MHC class II expression is differentially regulated in plasmacytoid and conventional dendritic cells.
Périodique
Nature Immunology
Auteur(s)
LeibundGut-Landmann S., Waldburger J.M., Reis e Sousa C., Acha-Orbea H., Reith W.
ISSN
1529-2908 (Print)
ISSN-L
1529-2908
Statut éditorial
Publié
Date de publication
2004
Volume
5
Numéro
9
Pages
899-908
Langue
anglais
Résumé
Major histocompatibility complex (MHC) class II-restricted antigen presentation is essential for the function of dendritic cells (DCs). We show here that plasmacytoid DCs (pDCs) differ from all other DC subsets with respect to expression of CIITA, the 'master regulator' of MHC class II genes. The gene encoding CIITA is controlled by three cell type-specific promoters: pI, pIII and pIV. With gene targeting in mice, we demonstrate that pDCs rely strictly on the B cell promoter pIII, whereas macrophages and all other DCs depend on pI. The molecular mechanisms driving MHC class II expression in pDCs are thus akin to those operating in lymphoid rather than myeloid cells.
Mots-clé
Animals, Antigen Presentation/immunology, B-Lymphocytes/immunology, Cell Lineage, Dendritic Cells/cytology, Dendritic Cells/immunology, Flow Cytometry, Gene Targeting, Genes, MHC Class II/physiology, Histocompatibility Antigens Class II/biosynthesis, Macrophages/immunology, Mice, Nuclear Proteins/biosynthesis, Nuclear Proteins/genetics, Promoter Regions, Genetic/physiology, Reverse Transcriptase Polymerase Chain Reaction, Trans-Activators/biosynthesis, Trans-Activators/genetics
Pubmed
Web of science
Création de la notice
24/01/2008 15:48
Dernière modification de la notice
03/03/2018 20:35
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