Aqueous humor dynamics in rats

Détails

ID Serval
serval:BIB_B11EF608292D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Aqueous humor dynamics in rats
Périodique
Graefe's Archive for Clinical and Experimental Ophthalmology
Auteur(s)
Mermoud  A., Baerveldt  G., Minckler  D. S., Prata, J. A., Jr. , Rao  N. A.
ISSN
0721-832X (Print)
Statut éditorial
Publié
Date de publication
08/1996
Volume
234 Suppl 1
Pages
S198-203
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Résumé
BACKGROUND: In order to determine normal outflow facility and aqueous humor production values in Lewis rats, we established methods of measuring aqueous humor dynamics in this animal. METHODS: Outflow facility was determined using anterior chamber infusion with constant pressure. Aqueous humor production was determined by a technique of dilution with FITC-albumin. RESULTS: The mean outflow facility was 0.044 +/- 0.01 microliter/min/mmHg. Rats weighing less than 300 g had lower values than did rats weighing more than 300 g (0.034 +/- 0.006 microliter/min/mmHg vs 0.050 +/- 0.015 microliter/min/mmHg, P = 0.009). The mean aqueous humor production was 0.350 +/- 0.110 microliter/min. The turnover rate of aqueous humor production per minute was 2.23%. CONCLUSIONS: Anterior chamber infusion with constant pressure and the FITC-albumin method allow measurement of the outflow facility and aqueous humor production in Lewis rats. These methods may be useful in assessing aqueous humor dynamics when rats are used as a glaucoma model.
Mots-clé
Animals Anterior Eye Segment/*physiology Aqueous Humor/cytology/*secretion Intraocular Pressure Lacrimal Apparatus/metabolism Organ Size Rats Rats, Inbred Lew Spectrometry, Fluorescence
Pubmed
Web of science
Création de la notice
28/01/2008 13:49
Dernière modification de la notice
03/03/2018 20:35
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