Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies.

Détails

ID Serval
serval:BIB_B10CB1D7C7A6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies.
Périodique
Therapeutic drug monitoring
Auteur(s)
Eap C.B., Jaquenoud Sirot E., Baumann P.
ISSN
0163-4356
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
26
Numéro
2
Pages
152-5
Langue
anglais
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Résumé
As for other drugs, there is a large interindividual variability of the plasma concentrations of antidepressants for a given dose. Within the last 2 decades, a very large number of pharmacogenetic studies have made it possible to understand the importance of genetic factors on the disposition of drugs in the organism, many of them at the levels of drug metabolism. Polymorphism of CYP2D6 and of other drug-metabolizing enzymes may thus lead to very large differences in drug exposure between patients and possibly also to toxicity or ineffective drug concentrations in some subjects. In consequence, dose recommendations of antidepressants based on genotypes, justified by the principle of administering bioequivalent individualized drug doses, are now proposed. However, blood (and thus possibly brain) concentrations also depend on other factors than the genetic makeup of the patients. Therapeutic drug monitoring of antidepressants allows us to take into account the influence of factors such as comedications, diet, smoking habit, impaired organ function, and compliance. Therapeutic drug monitoring and genotyping are thus complementary, and their combined use contributes to improve pharmacotherapy with antidepressants and other drugs.
Mots-clé
Antidepressive Agents, Clinical Trials as Topic, Cytochrome P-450 Enzyme System, Drug Monitoring, Genotype, Humans, Patient Compliance, Pharmacogenetics
Pubmed
Web of science
Création de la notice
10/03/2008 11:54
Dernière modification de la notice
03/03/2018 20:35
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