Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies.

Details

Serval ID
serval:BIB_B10CB1D7C7A6
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Therapeutic monitoring of antidepressants in the era of pharmacogenetics studies.
Journal
Therapeutic drug monitoring
Author(s)
Eap C.B., Jaquenoud Sirot E., Baumann P.
ISSN
0163-4356
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
26
Number
2
Pages
152-5
Language
english
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Abstract
As for other drugs, there is a large interindividual variability of the plasma concentrations of antidepressants for a given dose. Within the last 2 decades, a very large number of pharmacogenetic studies have made it possible to understand the importance of genetic factors on the disposition of drugs in the organism, many of them at the levels of drug metabolism. Polymorphism of CYP2D6 and of other drug-metabolizing enzymes may thus lead to very large differences in drug exposure between patients and possibly also to toxicity or ineffective drug concentrations in some subjects. In consequence, dose recommendations of antidepressants based on genotypes, justified by the principle of administering bioequivalent individualized drug doses, are now proposed. However, blood (and thus possibly brain) concentrations also depend on other factors than the genetic makeup of the patients. Therapeutic drug monitoring of antidepressants allows us to take into account the influence of factors such as comedications, diet, smoking habit, impaired organ function, and compliance. Therapeutic drug monitoring and genotyping are thus complementary, and their combined use contributes to improve pharmacotherapy with antidepressants and other drugs.
Keywords
Antidepressive Agents, Clinical Trials as Topic, Cytochrome P-450 Enzyme System, Drug Monitoring, Genotype, Humans, Patient Compliance, Pharmacogenetics
Pubmed
Web of science
Create date
10/03/2008 10:54
Last modification date
20/08/2019 15:20
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