A genome-wide association study of neuroticism in a population-based sample.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_B0C4E02333B9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A genome-wide association study of neuroticism in a population-based sample.
Périodique
Plos One
Auteur(s)
Calboli Federico C. F., Tozzi Federica, Galwey Nicholas W., Antoniades Athos, Mooser Vincent, Preisig Martin, Vollenweider Peter, Waterworth Dawn, Waeber Gerard, Johnson Michael R., Muglia Pierandrea, Balding David J.
ISSN
1932-6203[electronic], 1932-6203[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
5
Numéro
7
Pages
11504
Langue
anglais
Résumé
Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of population stratification, corrected using one principal component, and some cryptic kinship that required no correction. NKAIN2 showed suggestive evidence of association with neuroticism as a main effect (p < 10(-6)) and GPC6 showed suggestive evidence for interaction with age (p approximately = 10(-7)). We found support for one previously-reported association (PDE4D), but failed to replicate other recent reports. These results suggest common SNP variation does not strongly influence neuroticism. Our study was powered to detect almost all SNPs explaining at least 2% of heritability, and so our results effectively exclude the existence of loci having a major effect on neuroticism.
Mots-clé
Personality-Trait Neuroticism, Generalized Anxiety Disorder, Cardiovascular Risk-Factors, Major Depression, Linkage Analysis, Alzheimers-Disease, 1st Onset, Twin, Heritability, Genes , Colaus Study
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/07/2010 10:45
Dernière modification de la notice
20/08/2019 16:19
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