Preclinical Auger and gamma radiation dosimetry for fluorodeoxyuridine-enhanced tumour proliferation scintigraphy with [123I]iododeoxyuridine
Details
Serval ID
serval:BIB_B0A25242DB76
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Preclinical Auger and gamma radiation dosimetry for fluorodeoxyuridine-enhanced tumour proliferation scintigraphy with [123I]iododeoxyuridine
Journal
European Journal of Nuclear Medicine and Molecular Imaging
ISSN
1619-7070 (Print)
Publication state
Published
Issued date
02/2003
Volume
30
Number
2
Pages
239-46
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
Animal experiments have shown that short blocking of thymidine (dThd) synthesis with fluorodeoxyuridine (FdUrd) results in significantly increased DNA incorporation of [(125)I]iododeoxyuridine ([(125)I]IdUrd) in tumour and rapidly cycling tissues. Based on these results, we give an Auger and gamma radiation dosimetry estimate for a scintigraphy study in glioblastoma patients using [(123)I]IdUrd. The Auger radiation dosimetry calculated for patients is based on measurement of DNA-incorporated [(125)I]IdUrd in rapidly dividing tissues in nude mice xenografted with human glioblastoma. Further data obtained 0.5, 6 and 24 h after injection of [(125)I]IdUrd allowed calculation of the additional gamma radiation exposure using MIRDOSE3.1. High gradients of radioactivity concentration between dividing and non-dividing tissues were observed 6 and 24 h after injection of [(125)I]IdUrd combined with FdUrd pretreatment. While the estimated Auger radiation absorbed doses of [(123)I]IdUrd in six rapidly cycling normal tissues in patients are low, the equivalent doses become significant with application of the recommended preliminary radiation weighting factor (W(R)) of 20 for stochastic effects of DNA-associated Auger radiation. Using the latter W(R), extrapolation of the animal results to the proposed patient injection with 300 MBq [(123)I]IdUrd combined with FdUrd pretreatment indicates that the effective dose will be 5.42 mSv, including 1.67 mSv from Auger and 3.75 mSv from gamma radiation. The predicted Auger radiation effective dose for patients undergoing [(123)I]IdUrd scintigraphy will be significant if the enhancement of DNA incorporation that is achieved by means of FdUrd pretreatment is similar to that obtained in animals.
Keywords
Animals
Body Burden
Computer Simulation
DNA, Neoplasm/drug effects/metabolism
Drug Evaluation, Preclinical/methods
Drug Synergism
Electrons
Floxuridine/*administration & dosage
Gamma Rays
Glioblastoma/*metabolism/*radionuclide imaging
Humans
Idoxuridine/administration & dosage/diagnostic use/*pharmacokinetics
Male
Mice
Mice, Nude
Models, Biological
Neoplasm Transplantation
Organ Specificity
Radiation Dosage
Radiometry/*methods
Radiopharmaceuticals/diagnostic use/pharmacokinetics
Tissue Distribution
Tumor Cells, Cultured
Pubmed
Web of science
Create date
25/01/2008 12:22
Last modification date
20/08/2019 16:19