Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection
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State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
State: Public
Version: Final published version
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_B052FDB18CA6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection
Journal
Journal of Infectious Diseases
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
10/1997
Volume
176
Number
4
Pages
924-32
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Abstract
The role of neutralizing antibodies in human immunodeficiency virus type 1 (HIV-1) infection is poorly understood and was assessed by evaluating responses at different stages of infection. Undiluted sera from long-term nonprogressors (LTNP) had broad neutralizing antibodies against heterologous primary isolates and were more likely to neutralize the contemporaneous autologous isolate than were sera from short-term nonprogressors and progressors. In primary infection, envelope-specific IgG was detected before the initial decline in plasma viremia, but neutralizing antibodies developed more slowly. Here, neutralizing antibodies against strains SF-2 and MN were sometimes the first to be detected, but titers were low for at least 17 weeks from onset of symptoms. Neutralizing antibodies against the early autologous isolate were detected for 4 patients by 5-40 weeks but were undetectable in 2 additional patients for 27-45 weeks. The results indicate that neutralizing antibody responses are slow to develop during primary infection and are uniquely broad in LTNP.
Keywords
CD4 Lymphocyte Count
Cells, Cultured
HIV Antibodies/*analysis/*immunology
HIV Infections/*immunology
HIV-1/growth & development/*immunology
Humans
Immunoglobulin G/analysis/immunology
Leukocytes, Mononuclear
Macrophage Inflammatory Protein-1/analysis/immunology
*Neutralization Tests
RANTES/analysis/immunology
Survivors
Viral Load
Viremia/immunology
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 16:13
Last modification date
14/02/2022 8:56