The hourglass and the early conservation models--co-existing patterns of developmental constraints in vertebrates.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_B03DCB0498A7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The hourglass and the early conservation models--co-existing patterns of developmental constraints in vertebrates.
Périodique
Plos Genetics
Auteur(s)
Piasecka B., Lichocki P., Moretti S., Bergmann S., Robinson-Rechavi M.
ISSN
1553-7404 (Electronic)
ISSN-L
1553-7390
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
9
Numéro
4
Pages
e1003476
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Developmental constraints have been postulated to limit the space of feasible phenotypes and thus shape animal evolution. These constraints have been suggested to be the strongest during either early or mid-embryogenesis, which corresponds to the early conservation model or the hourglass model, respectively. Conflicting results have been reported, but in recent studies of animal transcriptomes the hourglass model has been favored. Studies usually report descriptive statistics calculated for all genes over all developmental time points. This introduces dependencies between the sets of compared genes and may lead to biased results. Here we overcome this problem using an alternative modular analysis. We used the Iterative Signature Algorithm to identify distinct modules of genes co-expressed specifically in consecutive stages of zebrafish development. We then performed a detailed comparison of several gene properties between modules, allowing for a less biased and more powerful analysis. Notably, our analysis corroborated the hourglass pattern at the regulatory level, with sequences of regulatory regions being most conserved for genes expressed in mid-development but not at the level of gene sequence, age, or expression, in contrast to some previous studies. The early conservation model was supported with gene duplication and birth that were the most rare for genes expressed in early development. Finally, for all gene properties, we observed the least conservation for genes expressed in late development or adult, consistent with both models. Overall, with the modular approach, we showed that different levels of molecular evolution follow different patterns of developmental constraints. Thus both models are valid, but with respect to different genomic features.
Mots-clé
Animals, Biological Evolution, Evolution, Molecular, Gene Duplication, Gene Expression Regulation, Developmental, Genome, Phylogeny, Zebrafish/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/10/2012 9:28
Dernière modification de la notice
08/05/2019 23:49
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