Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study.
Details
Serval ID
serval:BIB_B027C60B7224
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of depression and cognitive impairment on quality of life in older adults with schizophrenia spectrum disorder: Results from a multicenter study.
Journal
Journal of affective disorders
Working group(s)
CSA Study Group
Contributor(s)
Adès J., Alezrah C., Amado I., Amar G., Andréi O., Arbault D., Archambault G., Aurifeuille G., Barrière S., Béra-Potelle C., Blumenstock Y., Bardou H., Bareil-Guérin M., Barrau P., Barrouillet C., Baup E., Bazin N., Beaufils B., Ben Ayed J., Benoit M., Benyacoub K., Bichet T., Blanadet F., Blanc O., Blanc-Comiti J., Boussiron D., Bouysse A.M., Brochard A., Brochart O., Bucheron B., Cabot M., Camus V., Chabannes J.M., Charlot V., Charpeaud T., Clad-Mor C., Combes C., Comisu M., Cordier B., Costi F., Courcelles J.P., Creixell M., Cuche H., Cuervo-Lombard C., Dammak A., Da Rin D., Denis J.B., Denizot H., Deperthuis A., Diers E., Dirami S., Donneau D., Dreano P., Dubertret C., Duprat E., Duthoit D., Fernandez C., Fonfrede P., Freitas N., Gasnier P., Gauillard J., Getten F., Gierski F., Godart F., Gourevitch R., Grassin Delyle A., Gremion J., Gres H., Griner V., Guerin-Langlois C., Guggiari C., Guillin O., Hadaoui H., Haffen E., Hanon C., Haouzir S., Hazif-Thomas C., Heron A., Hoertel N., Hubsch B., Jalenques I., Januel D., Kaladjian A., Karnycheff J.F., Kebir O., Krebs M.O., Lajugie C., Leboyer M., Legrand P., Lejoyeux M., Lemaire V., Leroy E., Levy-Chavagnat D., Leydier A., Liling C., Limosin F., Llorca P.M., Loeffel P., Louville P., Lucas Navarro S., Mages N., Mahi M., Maillet O., Manetti A., Martelli C., Martin P., Masson M., Maurs-Ferrer I., Mauvieux J., Mazmanian S., Mechin E., Mekaoui L., Meniai M., Metton A., Mihoubi A., Miron M., Mora G., Niro Adès V., Nubukpo P., Omnes C., Papin S., Paris P., Passerieux C., Pellerin J., Perlbarg J., Perron S., Petit A., Petitjean F., Portefaix C., Pringuey D., Radtchenko A., Rahiou H., Raucher-Chéné D., Rauzy A., Reinheimer L., Renard M., René M., Rengade C.E., Reynaud P., Robin D., Rodrigues C., Rollet A., Rondepierre F., Rousselot B., Rubingher S., Saba G., Salvarelli J.P., Samuelian J.C., Scemama-Ammar C., Schurhoff F., Schuster J.P., Sechter D., Segalas B., Seguret T., Seigneurie A.S., Semmak A., Slama F., Taisne S., Taleb M., Terra J.L., Thefenne D., Tran E., Tourtauchaux R., Vacheron M.N., Vandel P., Vanhoucke V., Venet E., Verdoux H., Viala A., Vidon G., Vitre M., Vurpas J.L., Wagermez C., Walter M., Yon L., Zendjidjian X.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
01/09/2019
Peer-reviewed
Oui
Volume
256
Pages
164-175
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Little is known about the respective effects of depression and cognitive impairment on quality of life among older adults with schizophrenia spectrum disorder.
We used data from the Cohort of individuals with Schizophrenia Aged 55-years or more (CSA) study, a large multicenter sample of older adults with schizophrenia or schizoaffective disorder (N = 353). Quality of life (QoL), depression and cognitive impairment were assessed using the Quality of Life Scale (QLS), the Center of Epidemiologic Studies Depression scale and the Mini-Mental State Examination, respectively. We used structural equation modeling to examine the shared and specific effects of depression and cognitive impairment on QoL, while adjusting for sociodemographic characteristics, general medical conditions, psychotropic medications and the duration of the disorder.
Depression and cognitive impairment were positively associated (r = 0.24, p < 0.01) and both independently and negatively impacted on QoL (standardized β = -0.41 and β = -0.32, both p < 0.01) and on each QLS quality-of-life domains, except for depression on instrumental role and cognitive impairment on interpersonal relations in the sensitivity analyses excluding respondents with any missing data. Effects of depression and cognitive impairment on QoL were not due to specific depressive symptoms or specific cognitive domains, but rather mediated through two broad dimensions representing the shared effects across all depressive symptoms and all cognitive deficits, respectively.
Because of the cross-sectional design of this study, measures of association do not imply causal associations.
Mechanisms underlying these two broad dimensions should be considered as important potential targets to improve quality of life of this vulnerable population.
We used data from the Cohort of individuals with Schizophrenia Aged 55-years or more (CSA) study, a large multicenter sample of older adults with schizophrenia or schizoaffective disorder (N = 353). Quality of life (QoL), depression and cognitive impairment were assessed using the Quality of Life Scale (QLS), the Center of Epidemiologic Studies Depression scale and the Mini-Mental State Examination, respectively. We used structural equation modeling to examine the shared and specific effects of depression and cognitive impairment on QoL, while adjusting for sociodemographic characteristics, general medical conditions, psychotropic medications and the duration of the disorder.
Depression and cognitive impairment were positively associated (r = 0.24, p < 0.01) and both independently and negatively impacted on QoL (standardized β = -0.41 and β = -0.32, both p < 0.01) and on each QLS quality-of-life domains, except for depression on instrumental role and cognitive impairment on interpersonal relations in the sensitivity analyses excluding respondents with any missing data. Effects of depression and cognitive impairment on QoL were not due to specific depressive symptoms or specific cognitive domains, but rather mediated through two broad dimensions representing the shared effects across all depressive symptoms and all cognitive deficits, respectively.
Because of the cross-sectional design of this study, measures of association do not imply causal associations.
Mechanisms underlying these two broad dimensions should be considered as important potential targets to improve quality of life of this vulnerable population.
Keywords
Aged, Aged, 80 and over, Cognitive Dysfunction/psychology, Cohort Studies, Cross-Sectional Studies, Depression/psychology, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Quality of Life/psychology, Schizophrenia/complications, Schizophrenic Psychology, Cognition, Depression, Elderly, Older adults, Quality of life, Schizoaffective disorder, Schizophrenia
Pubmed
Web of science
Open Access
Yes
Create date
05/05/2023 16:04
Last modification date
13/05/2023 5:51
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