ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study.
Details
Serval ID
serval:BIB_AFEBDCCC8516
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study.
Journal
Journal of advanced nursing
Working group(s)
GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS)
Contributor(s)
Berben L., Burkhalter H., Denhaerynck K., Helmy R., Kirsch M., Leppla L., Struker M., Boehler A., Gerull S., Koller M.T., Boely E., Catana E., Simcox A., Seiler A., Klaghofer R., Künzler-Heule P., Beckmann S., Achermann R., Amico P., Aubert J.D., Baumann P., Beldi G., Benden C., Berger C., Bochud P.Y., Boely E., Bucher H., Bühler L., Carell T., Catana E., Chalandon Y., de Rougemont O., Duchosal M., Fehr T., Ferrari-Lacraz S., Garzoni C., Soccal P.G., Giostra E., Halter J., Heim D., Hess C., Hillinger S., Hirsch H.H., Hofbauer G., Immer F., Klaghofer R., Koller M., Laesser B., Lehmann R., Lovis C., Manuel O., Marti H.P., Martin P.Y., Martinolli L., Meylan P., Mohacsi P., Morard I., Morel P., Mueller U., Mueller N.J., Mueller-McKenna H., Müller A., Müller T., Müllhaupt B., Nadal D., Pascual M., Passweg J., Ziegler C.P., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schanz U., Schaub S., Schnyder A., Seiler C., Stampf S., Steiger J., Stirnimann G., Toso C., Van Delden C., Venetz J.P., Villard J., Wick M., Wilhelm M., Yerly P.
ISSN
1365-2648 (Electronic)
ISSN-L
0309-2402
Publication state
Published
Issued date
03/2017
Peer-reviewed
Oui
Volume
73
Number
3
Pages
716-734
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
To present the rationale, design and methodology of the GERAS project, which examines whether assessment of frailty and mild cognitive impairment could enhance risk prediction for biomedical, psychosocial outcomes and foster efficient resource allocation in kidney transplantation.
For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision-making and medical management. As known risk factors for 'hard' clinical outcomes in chronic illness, both require further study in transplantation. Integrating these and other bio-psychosocial factors into a comprehensive pre-transplant patient assessment will provide insights regarding economic implications and may improve risk prediction.
A nation-wide multi-centre prospective cohort study nested in the Swiss Transplant Cohort Study.
Our nationally representative convenience sample includes 250 adult kidney transplant recipients. Data sources include the Swiss Transplant Cohort Study and primary data collected at time of transplantation, 6 months, 1 and 2 years post-transplant via established measures (the Montreal Cognitive Assessment, Psychosocial Questionnaire, Fried Frailty Instrument and a blood analysis), investigator-developed instruments and datasets compiled by hospitals' management control units, sickness funds, the Swiss Federal Statistical Office and the European Renal Association. Descriptive, competing risk survival and mixed effects analyses will be performed. Research Ethics Committee approval was obtained in January 2016.
This pioneering project jointly examines frailty and mild cognitive impairment from bio-psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort.
For the burgeoning cohort of older patients considered for kidney transplantation, evidence gaps regarding frailty and mild cognitive impairment limit clinical decision-making and medical management. As known risk factors for 'hard' clinical outcomes in chronic illness, both require further study in transplantation. Integrating these and other bio-psychosocial factors into a comprehensive pre-transplant patient assessment will provide insights regarding economic implications and may improve risk prediction.
A nation-wide multi-centre prospective cohort study nested in the Swiss Transplant Cohort Study.
Our nationally representative convenience sample includes 250 adult kidney transplant recipients. Data sources include the Swiss Transplant Cohort Study and primary data collected at time of transplantation, 6 months, 1 and 2 years post-transplant via established measures (the Montreal Cognitive Assessment, Psychosocial Questionnaire, Fried Frailty Instrument and a blood analysis), investigator-developed instruments and datasets compiled by hospitals' management control units, sickness funds, the Swiss Federal Statistical Office and the European Renal Association. Descriptive, competing risk survival and mixed effects analyses will be performed. Research Ethics Committee approval was obtained in January 2016.
This pioneering project jointly examines frailty and mild cognitive impairment from bio-psychosocial and health economic perspectives. Results may significantly inform risk prediction, care tailoring and resource optimization to improve health outcomes in the ageing kidney transplant cohort.
Pubmed
Web of science
Create date
19/10/2016 11:24
Last modification date
27/01/2024 7:36
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