Association between mannose-binding lectin deficiency and cytomegalovirus infection after kidney transplantation.

Détails

ID Serval
serval:BIB_AFC6EC9F56E6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association between mannose-binding lectin deficiency and cytomegalovirus infection after kidney transplantation.
Périodique
Transplantation
Auteur(s)
Manuel O., Pascual M., Trendelenburg M., Meylan P.R.
ISSN
0041-1337
Statut éditorial
Publié
Date de publication
02/2007
Peer-reviewed
Oui
Volume
83
Numéro
3
Pages
359-362
Langue
anglais
Notes
Journal Article --- Old month value: Feb 15
Résumé
Mannose-binding lectin (MBL) deficiency has been suggested as a risk factor for certain viral infections. However, there is no data about the possible association between MBL deficiency and cytomegalovirus (CMV) infection, especially after organ transplantation. We measured plasma MBL levels in 16 kidney transplant recipients with high-risk CMV serostatus (donor-positive/recipient-negative). MBL deficiency was diagnosed if MBL levels were <500 ng/mL. Of these 16 patients, seven developed CMV disease, four developed asymptomatic CMV infection, and in five patients CMV replication was not detected. Overall, 9 of 16 patients (56%) had MBL deficiency: five of seven (71%) patients with CMV disease, four of four (100%) patients with asymptomatic CMV infection, and zero of five (0%) patients without CMV infection (P=0.005; CMV infection/disease versus no infection). MBL deficiency may be a significant risk factor for the development of CMV infection in kidney transplant recipients, suggesting a role for innate immunity in the control of CMV infection after organ transplantation.
Mots-clé
Adult, Aged, Cytomegalovirus Infections, Female, Humans, Kidney Transplantation, Male, Mannose-Binding Lectin, Middle Aged, Risk Factors
Pubmed
Web of science
Création de la notice
25/01/2008 14:33
Dernière modification de la notice
20/08/2019 15:19
Données d'usage