Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing

Détails

Ressource 1Télécharger: fimmu-08-01558.pdf (1434.92 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_AF9E161610CB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Survival Mechanisms Used by Some Leishmania Species to Escape Neutrophil Killing
Périodique
Frontiers in Immunology
Auteur(s)
Regli I.B., Passelli K., Hurrell B.P., Tacchini-Cottier F.
ISSN
1664-3224
Statut éditorial
Publié
Date de publication
16/11/2017
Peer-reviewed
Oui
Volume
8
Pages
1558
Langue
anglais
Résumé
Neutrophils are the most abundant leukocytes in human blood. Upon microbial infection, they are massively and rapidly recruited from the circulation to sites of infection where they efficiently kill pathogens. To this end, neutrophils possess a variety of weapons that can be mobilized and become effective within hours following infection. However, several microbes including some Leishmania spp. have evolved a variety of mechanisms to escape neutrophil killing using these cells as a basis to better invade the host. In addition, neutrophils are also present in unhealing cutaneous lesions where their role remains to be defined. Here, we will review recent progress in the field and discuss the different strategies applied by some Leishmania parasites to escape from being killed by neutrophils and as recently described for Leishmania mexicana, even replicate within these cells. Subversion of neutrophil killing functions by Leishmania is a strategy that allows parasite spreading in the host with a consequent deleterious impact, transforming the primary protective role of neutrophils into a deleterious one.
Mots-clé
Leishmania, neutrophils, Leishmania survival, neutrophil extracellular traps, reactive oxygen species, neutrophil granules, Leishmania replication
Web of science
Open Access
Oui
Création de la notice
01/12/2017 10:46
Dernière modification de la notice
20/08/2019 16:19
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